ArticleThe Journal of clinical investigation2003
Decreased elastin in vessel walls puts the pressure on.
Article in The Journal of clinical investigation, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 38 citations in OpenAlex.
- Distinct populations of lung capillary endothelial cells and their functional significance.Communications biology · 2025Article
- Deciphering the Complexities of Pulmonary Hypertension: The Emergent Role of Single-Cell Omics.American journal of respiratory cell and molecular biology · 2025Review
- Novel Populations of Lung Capillary Endothelial Cells and Their Functional Significance.Research square · 2023Article
- Mechanical Properties and Functions of Elastin: An Overview.Biomolecules · 2023Review
- Shared genetic architecture between neuroticism, coronary artery disease and cardiovascular risk factors.Translational psychiatry · 2021Article
- Elastin-Derived Peptides Promote Abdominal Aortic Aneurysm Formation by Modulating M1/M2 Macrophage Polarization.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Advances in biomimetic regeneration of elastic matrix structures.Drug delivery and translational research · 2012Article
- Substantial expression of mature elastin in arterial constructs.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Tempol, a superoxide dismutase mimetic, prevents cerebral vessel remodeling in hypertensive rats.Microvascular research · 2010Article
- Copper nanoparticle cues for biomimetic cellular assembly of crosslinked elastin fibers.Acta biomaterialia · 2009Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mice haploinsufficient for elastin develop structural changes in vessel walls similar to those seen in patients with mutations in the elastin gene. A new study demonstrates that due to mechanical changes in the vessel wall, these animals exhibit increased mean arterial pressures. The results evoke the possibility that alterations in elastin may contribute to the development of essential hypertension in patients.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.