ArticleThe Journal of experimental medicine2003
Age-dependent requirement for gammadelta T cells in the primary but not secondary protective immune response against an intestinal parasite.
Article in The Journal of experimental medicine, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 99 citations in OpenAlex.
- Congenital cytomegalovirus infection drives oligoclonal expansion of cytotoxic γδ T cells from early fetal progenitors.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Epithelial chemokine CCL25 integrates T cell development and intestinal homeostasis.The Journal of experimental medicine · 2026Article
- Human γδ T cells in diverse tissues exhibit site-specific maturation dynamics across the life span.Science immunology · 2024Article
- Development of γδ T Cells: Soldiers on the Front Lines of Immune Battles.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Identification of distinct functional thymic programming of fetal and pediatric human γδ thymocytes via single-cell analysis.Nature communications · 2022Article
- γδ T Cells in Brain Homeostasis and Diseases.Frontiers in immunology · 2022Review
- Article
- γδ T cells in tissue physiology and surveillance.Nature reviews. Immunology · 2021Review
- Malaria and Early Life Immunity: Competence in Context.Frontiers in immunology · 2021Review
- γδ T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis.Mucosal immunology · 2020Article
- Fetal public Vγ9Vδ2 T cells expand and gain potent cytotoxic functions early after birth.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Type 1 TNature immunology · 2020Article
- Review
- The immune response to malaria in utero.Immunological reviews · 2020Review
- Parasite infections in a social carnivore: Evidence of their fitness consequences and factors modulating infection load.Ecology and evolution · 2019Article
- Article
- Genetic models reveal origin, persistence and non-redundant functions of IL-17-producing γδ T cells.The Journal of experimental medicine · 2018Article
- Mitochondria maintain controlled activation state of epithelial-resident T lymphocytes.Science immunology · 2018Article
- Policing the intestinal epithelial barrier: Innate immune functions of intraepithelial lymphocytes.Current pathobiology reports · 2018Article
- CD73 expression identifies a subset of IgMImmunology · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Between weaning (3 wk of age) and adulthood (7 wk of age), mice develop increased resistance to infection with Eimeria vermiformis, an abundant intestinal parasite that causes coccidiosis. This development of resistance was perturbed in T cell receptor (TCR)delta(-/-) mice, which at 4 wk of age remained largely susceptible to infection and prone to infection-associated dehydration. These phenotypes were rescued by the repopulation of gammadelta cells after adoptive transfer of lymphoid progenitors into newborn recipients. Because alphabeta T cells are necessary and sufficient for the protection of adult mice against E. vermiformis, the requirement for gammadelta cells in young mice shows a qualitative difference between the cellular immune responses operating at different ages. An important contribution toward primary immune protection in young hosts may have provided a strong selective pressure for the evolutionary conservation of gammadelta cells. This notwithstanding, the development of effective, pathogen-specific immunity in young mice requires alphabeta T cells, just as it does in adult mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.