ArticleThe Journal of experimental medicine2003
Down-regulation of CD46 by piliated Neisseria gonorrhoeae.
Article in The Journal of experimental medicine, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 53 citations in OpenAlex.
- Article
- Mechanisms of host manipulation byFrontiers in microbiology · 2023Review
- Article
- Neisseria gonorrhoeae evades autophagic killing by downregulating CD46-cyt1 and remodeling lysosomes.PLoS pathogens · 2019Article
- Pathogenesis ofFrontiers in immunology · 2018Review
- CD46 processing: a means of expression.Immunobiology · 2012Review
- Adenovirus type-35 vectors block human CD4+ T-cell activation via CD46 ligation.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- CD46 plasticity and its inflammatory bias in multiple sclerosis.Archivum immunologiae et therapiae experimentalis · 2011Review
- Dynamic control of the complement system by modulated expression of regulatory proteins.Laboratory investigation; a journal of technical methods and pathology · 2011Review
- Transcellular passage of Neisseria meningitidis across a polarized respiratory epithelium.Infection and immunity · 2010Article
- Mechanism of neuroinflammation: enhanced cytotoxicity and IL-17 production via CD46 binding.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2010Article
- The complement inhibitors Crry and factor H are critical for preventing autologous complement activation on renal tubular epithelial cells.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Presenilin/gamma-secretase cleaves CD46 in response to Neisseria infection.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- CD46 Contributes to the severity of group A streptococcal infection.Infection and immunity · 2008Article
- IFN-gamma amplifies NFkappaB-dependent Neisseria meningitidis invasion of epithelial cells via specific upregulation of CEA-related cell adhesion molecule 1.Cellular microbiology · 2007Article
- Downregulation of human CD46 by adenovirus serotype 35 vectors.Gene therapy · 2007Article
- Monoclonal antibody detection of CD46 clustering beneath Neisseria gonorrhoeae microcolonies.Infection and immunity · 2006Article
- Emerging roles and new functions of CD46.Springer seminars in immunopathology · 2005Review
- CD46-independent binding of neisserial type IV pili and the major pilus adhesin, PilC, to human epithelial cells.Infection and immunity · 2005Article
- Gonorrhea Update.Current infectious disease reports · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Human membrane cofactor protein (CD46) protects host cells against complement attack and may function as a receptor for pathogenic Neisseriae. We assessed CD46 expression in the human cervical cell line ME-180 after exposure to Neisseria gonorrhoeae. Piliated but not nonpiliated gonococci adhered to cells and produced up to an 80% reduction in CD46 surface expression by 6 h that persisted for at least 24 h. This response required a minimum multiplicity of infection of 10 and was not prevented by antibodies to CD46. CD46 down-regulation was not attributable to intracellular retention or a global or specific shutdown of mRNA or protein synthesis. Substantial quantities of CD46 were found in the supernatants, indicating a specific shedding of this protein. Adherent gonococci lacking the pilus retraction protein PilT did not down-regulate CD46 but de-repression of pilT expression restored CD46 down-regulation. After experimental infection of human volunteers with a gonococcal variant incapable of inducing CD46 down-regulation, variants of this strain were reisolated that exhibited CD46 down-regulation. Pilus-mediated interactions of gonococci with human epithelial cells results in a pathogen-induced manipulation of the host cell environment in which a membrane protein is removed from epithelial cells by liberation into the surrounding milieu.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.