ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2003
Adaptive differences in the structure and macromolecular compositions of the air and water corneas of the "four-eyed" fish (Anableps anableps).
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- Opsin gene evolution in aquatic, amphibious and terrestrial blennies (Blenniidae).Biology open · 2026Article
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- Development of convergent adaptations reveal highly conserved early ontogenetic skull shape in fishes with amphibious vision.Scientific reports · 2025Article
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- Eye development in the four-eyed fishProceedings. Biological sciences · 2017Article
- A Comparative Study of Vertebrate Corneal Structure: The Evolution of a Refractive Lens.Investigative ophthalmology & visual science · 2015Article
- Ocular surface development and gene expression.Journal of ophthalmology · 2013Article
- The visual system of zebrafish and its use to model human ocular diseases.Developmental neurobiology · 2012Review
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- Toward a better understanding of human eye disease insights from the zebrafish, Danio rerio.Progress in molecular biology and translational science · 2011Review
- Distribution of carnosine-like peptides in the nervous system of developing and adult zebrafish (Danio rerio) and embryonic effects of chronic carnosine exposure.Cell and tissue research · 2009Article
- Corneal crystallins and the development of cellular transparency.Seminars in cell & developmental biology · 2008Review
- Duplicated gelsolin family genes in zebrafish: a novel scinderin-like gene (scinla) encodes the major corneal crystallin.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2007Article
- Corneal keratocytes: phenotypic and species differences in abundant protein expression and in vitro light-scattering.Investigative ophthalmology & visual science · 2005Article
- Morphogenesis of the anterior segment in the zebrafish eye.BMC developmental biology · 2005Article
- Abundant corneal gelsolin in Zebrafish and the 'four-eyed' fish, Anableps anableps: possible analogy with multifunctional lens crystallins.Experimental eye research · 2004Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
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Abstract
The water meniscus bisects the eyes of the "four-eyed" fish Anableps anableps, resulting in simultaneous vision in air and water. We compare the structure and macromolecular compositions of the Anableps dorsal (air) and ventral (water) corneas with the fully aquatic zebrafish cornea. The Anableps dorsal corneal epithelium is thicker (>20 cell layers), flatter (approximately 1.94 mm radius of curvature), and contains approximately 15-fold more glycogen (0.16 microg/microg water-soluble protein) than the ventral corneal epithelium (5-7 cell layers; approximately 1.63 mm radius of curvature; 0.01 microg glycogen/microg water-soluble protein), which resembles the zebrafish corneal epithelium. Gelsolin is the major water-soluble protein in the zebrafish (approximately 50%) and Anableps dorsal (approximately 38%) and ventral (approximately 21%) corneal epithelia, suggesting that gelsolin was recruited for high corneal expression before these two species diverged at least 100 million years ago and that abundant corneal gelsolin is not limited to aquatic vision. Anableps gelsolin, deduced from its cDNA, is 57% identical to zebrafish gelsolin. Paucity of Anableps corneal F-actin (consistent with high gelsolin) was confirmed by the absence of rhodamine-phalloidin staining. We suggest amphibious refraction and protection from UV irradiation and desiccation in air as selective constraints for the specializations of the Anableps dorsal cornea.
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