ArticleNeurogenetics2004
Investigation of seven proposed regions of linkage in multiple sclerosis: an American and French collaborative study.
Article in Neurogenetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Mapping candidate non-MHC susceptibility regions to multiple sclerosis.Genes and immunity · 2006Pooled it
- Identity-by-descent mapping in a Scandinavian multiple sclerosis cohort.European journal of human genetics : EJHG · 2015Article
- Role of apolipoprotein E in neurodegenerative diseases.Neuropsychiatric disease and treatment · 2015Review
- A follow-up study of chromosome 19q13 in multiple sclerosis susceptibility.Journal of neuroimmunology · 2009Article
- Genes implicated in multiple sclerosis pathogenesis from consilience of genotyping and expression profiles in relapse and remission.BMC medical genetics · 2008Article
- Gene expression studies in multiple sclerosis.Current genomics · 2007Article
- Follow-up investigation of 12 proposed linkage regions in multiple sclerosis.Genes and immunity · 2006Article
- Genes and autoimmune diseases - a complex inheritance.MedGenMed : Medscape general medicine · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 10 institutions in 2 countries.
Funding
Abstract
Multiple sclerosis (MS) is a demyelinating autoimmune disease with a strong yet complex genetic component. To date only the HLA-DR locus, and specifically the HLA-DR15 allele, has been identified and confirmed as influencing the risk of developing MS. Genomic screens on several datasets have been performed and have identified several chromosomal regions with interesting results, but none have yet been confirmed. We tested seven of the most-promising regions (on chromosomes 1p, 2p, 3p, 3q, 5q, 19q, and Xp) identified from several genomic screens in a dataset of 98 multiplex MS families from the United States and 90 multiplex MS families from France. The results did not confirm linkage to 2p, 3q, 5q, or Xp in the overall dataset, or in subsets defined by geographic origin or HLA-DR15 status. Regions on 1p34, 3p14, and 19q13 produced lod scores >0.90 in at least one subset of the data, suggesting that these regions should be examined in more detail.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.