ArticleCurrent genetics2004
The Neurospora crassa mus-19 gene is identical to the qde-3 gene, which encodes a RecQ homologue and is involved in recombination repair and postreplication repair.
Article in Current genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 31 citations in OpenAlex.
- Fungal small RNA: unveiling the breakthroughs and promising applications.Frontiers in fungal biology · 2025Review
- The LSH/DDM1 Homolog MUS-30 Is Required for Genome Stability, but Not for DNA Methylation in Neurospora crassa.PLoS genetics · 2016Article
- Gene targeting in the oil-producing fungus Mortierella alpina 1S-4 and construction of a strain producing a valuable polyunsaturated fatty acid.Current genetics · 2015Article
- Global Analysis of Predicted G Protein-Coupled Receptor Genes in the Filamentous Fungus, Neurospora crassa.G3 (Bethesda, Md.) · 2015Article
- Improved gene targeting frequency in marine-derived filamentous fungus Aspergillus glaucus by disrupting ligD.Journal of applied genetics · 2012Article
- RNA interference pathways in fungi: mechanisms and functions.Annual review of microbiology · 2012Review
- Global analysis of serine-threonine protein kinase genes in Neurospora crassa.Eukaryotic cell · 2011Article
- RNA interference pathways in filamentous fungi.Cellular and molecular life sciences : CMLS · 2010Review
- The DNA/RNA-dependent RNA polymerase QDE-1 generates aberrant RNA and dsRNA for RNAi in a process requiring replication protein A and a DNA helicase.PLoS biology · 2010Article
- Distinct roles of RECQ1 in the maintenance of genomic stability.DNA repair · 2010Review
- Unique and important consequences of RECQ1 deficiency in mammalian cells.Cell cycle (Georgetown, Tex.) · 2008Article
- Deletion of the cpku80 gene in the chestnut blight fungus, Cryphonectria parasitica, enhances gene disruption efficiency.Current genetics · 2008Article
- Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges.PloS one · 2007Article
- Rapid genetic mapping in Neurospora crassa.Fungal genetics and biology : FG & B · 2007Article
- Human premature aging, DNA repair and RecQ helicases.Nucleic acids research · 2007Review
- Nonhomologous chromosomal integration of foreign DNA is completely dependent on MUS-53 (human Lig4 homolog) in Neurospora.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Article
- Srs2 and RecQ homologs cooperate in mei-3-mediated homologous recombination repair of Neurospora crassa.Nucleic acids research · 2005Article
- Highly efficient gene replacements in Neurospora strains deficient for nonhomologous end-joining.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An allele called mus-19 was identified by screening temperature-sensitive and mutagen-sensitive mutants of Neurospora crassa. The mus-19 gene was genetically mapped to a region near the end of the right arm of linkage group I, where a RecQ homologue called qde-3 had been physically mapped in the Neurospora database. Complementation tests between the mus-19 mutant and the qde-3(RIP) mutant showed that mus-19 and qde-3 were the same gene. The qde-3 genes of both mutants were cloned and sequenced; and the results showed that they have mutation(s) in their qde-3 genes. The original mus-19 and qde-3(RIP) mutants are defective in quelling, as reported for other qde-3 mutants. The mutants show high sensitivity to methyl methanesulfonate, ethyl methanesulfonate, N-methyl- N'-nitro- N-nitrosoguanidine, tert-butyl hydroperoxide, 4-nitroquinoline-1-oxide, hydroxyurea and histidine. Epistasis analysis indicated that the qde-3 gene belongs both to the uvs-6 recombination repair pathway and the uvs-2 postreplication repair pathway. The qde-3 mutation has no effect on the integration of a plasmid carrying the mtr gene by homologous recombination. In homozygous crosses, the qde-3 mutant is defective in ascospore production.
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