ArticleJournal of the Royal Society of Medicine2003
Treatment for newly diagnosed hypertension: patterns of prescribing and antihypertensive effectiveness in the UK.
Article in Journal of the Royal Society of Medicine, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 52 citations in OpenAlex.
- Printed educational messages fail to increase use of thiazides as first-line medication for hypertension in primary care: a cluster randomized controlled trial [ISRCTN72772651].Implementation science : IS · 2016Trial
- Goal attainment, medication adherence and guideline adherence in the treatment of hypertension and dyslipidemia in Irish populations: A systematic review and meta-analysis.International journal of cardiology. Cardiovascular risk and prevention · 2025Review
- Non-persistence to antihypertensive drug therapy in Lithuania.European journal of clinical pharmacology · 2022Article
- Article
- Prescription of pharmacotherapy and blood pressure control among hypertensive outpatients in two semi-urban hospitals in Cameroon: a cross-sectional study.The Pan African medical journal · 2020Article
- Patients With Newly Diagnosed Hypertension Treated With the Renin Angiotensin Receptor Blocker Azilsartan Medoxomil vs Angiotensin-Converting Enzyme Inhibitors: The Prospective EARLY Registry.Journal of clinical hypertension (Greenwich, Conn.) · 2015Observational
- The impact of the 'Better Care Better Value' prescribing policy on the utilisation of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers for treating hypertension in the UK primary care setting: longitudinal quasi-experimental design.BMC health services research · 2015Article
- Benefit of initial dual-therapy on stroke prevention in Chinese hypertensive patients: a real world cohort study.Journal of thoracic disease · 2015Article
- Assessment of prescribing, dispensing, and patient use pattern of antihypertensive drugs for patients attending outpatient department of Hiwot Fana Specialized University Hospital, Harar, Eastern Ethiopia.Drug design, development and therapy · 2015Article
- Impact of ethnic-specific guidelines for anti-hypertensive prescribing in primary care in England: a longitudinal study.BMC health services research · 2014Article
- The use of epidemiological measures to estimate the impact of primary prevention interventions on CHD, stroke and cancer outcomes: experiences from Herefordshire, UK.Journal of epidemiology and global health · 2012Article
- Oversight: a retrospective study of biochemical monitoring in patients beginning antihypertensive drug treatment in primary care.British journal of clinical pharmacology · 2010Article
- Individuals at risk of beta-blocker discontinuation: a cohort study in 19,177 Chinese patients.Clinical research in cardiology : official journal of the German Cardiac Society · 2010Article
- Utilisation of angiotensin receptor blockers in Sweden: combining survey and register data to study adherence to prescribing guidelines.European journal of clinical pharmacology · 2008Article
- Patterns of antihypertensive prescribing, discontinuation and switching among a Hong Kong Chinese population from over one million prescriptions.Journal of human hypertension · 2008Article
- Antihypertensive medication prescription patterns and time trends for newly-diagnosed uncomplicated hypertension patients in Taiwan.BMC health services research · 2008Article
- The economic consequences of noncompliance in cardiovascular disease and related conditions: a literature review.International journal of clinical practice · 2008Review
- Choice of first antihypertensive--are existing guidelines ignored?British journal of clinical pharmacology · 2007Review
- Hypertension guideline recommendations in general practice: awareness, agreement, adoption, and adherence.The British journal of general practice : the journal of the Royal College of General Practitioners · 2007Article
- Preference for pharmacological management of patients with essential hypertension among senior physicians within Northern Ireland.Journal of human hypertension · 2007Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Improved practice in the management of hypertension depends on an understanding of existing patterns of treatment. To describe the management of newly diagnosed hypertension in British general practice and the effectiveness of current prescribing patterns we conducted a retrospective observational study using data from a computerized general practitioner record database (DIN-LINK). 21 024 patients were first treated for newly diagnosed hypertension between January 1993 and December 1997, and were followed for 4 years. Diuretics or beta-blockers were the most widely prescribed first-line treatments, used in 54% of patients. The mean continuation rate for first-line therapy was 69% at 12 months: the continuation rate was highest for angiotensin converting enzyme inhibitors/angiotensin II receptor antagonists. After 12 months of treatment the mean blood pressure reduction was 19/10 mmHg. Blood pressure targets were met in only 14% of patients. After 48 months of treatment 34% of patients had not improved in band of blood pressure severity. Many patients with severe hypertension at 12 months were still being prescribed only one drug. The lack of aggression in antihypertensive treatment, indicated by the low number of agents prescribed and the failure to achieve targets, is disappointing. Prescribing patterns for first-line therapy corresponded to guidelines. Continuation rates on first-line therapy were higher than often reported. The choice of drug for additions to or switches from first-line therapy had no clear pattern. Routinely collected computerized data could be used to support clinical governance activities in primary care.
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