Trial reportHeart (British Cardiac Society)2003
Effects of digoxin on left atrial function in heart failure.
Trial report in Heart (British Cardiac Society), 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Effect of Digoxin vs Beta-Blockers on Left Atrial Strain for Heart Rate-Controlled Atrial Fibrillation: The DIGOBET-AF Randomized Clinical Trial.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2025Trial
- A review of rate control in atrial fibrillation, and the rationale and protocol for the RATE-AF trial.BMJ open · 2017Trial
- Effect of beta-blocker therapy on left atrial function in patients with heart failure: comparison of metoprolol succinate with carvedilol.The international journal of cardiovascular imaging · 2007Trial
- A Platform for Assessing Cellular Contractile Function Based on Magnetic Manipulation of Magnetoresponsive Hydrogel Films.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- The Predictive Value of the Left Atrial Kinetic Energy for Atrial Fibrillation Recurrence.Cureus · 2022Article
- Disturbed Left Atrial Function is Associated with Paroxysmal Atrial Fibrillation in Hypertension.Arquivos brasileiros de cardiologia · 2014Article
- Evaluation of left atrial systolic function in noncompaction cardiomyopathy by real-time three-dimensional echocardiography.The international journal of cardiovascular imaging · 2008Article
- Echocardiographic assessment of left atrial ejection force and kinetic energy in chronic heart failure.The international journal of cardiovascular imaging · 2008Article
- Left atrial Frank-Starling law assessed by real-time, three-dimensional echocardiographic left atrial volume changes.Heart (British Cardiac Society) · 2007Article
- Left atrial reverse remodeling in dogs with moderate and advanced heart failure treated with a passive mechanical containment device: an echocardiographic study.Journal of cardiac failure · 2007Article
- Assessment of cardiac risk before non-cardiac surgery: brain natriuretic peptide in 1590 patients.Heart (British Cardiac Society) · 2006Article
- Aortic stiffness in children of parents with hypertension.Journal of human hypertension · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the effects of digoxin on left atrial (LA) function in patients with congestive heart failure and dilated left atria. PATIENTS: 30 patients with enlarged left atrium (maximum LA diameter > 4 mm) caused by heart failure (New York Heart Association functional class III or IV) were studied before and after treatment with digoxin (0.25 mg orally for 12 days). Digoxin was also administered to 30 normal participants who served as controls.
main outcome measuresLA active (AEF) and passive emptying fractions (PEF), reservoir fraction (RF), kinetic energy (KE), and mean velocity of circumferential atrial fibre shortening (Vcf) were calculated from echocardiographic measurements of LA volumes and transmitral Doppler flow velocities at baseline and on the third, sixth, eighth, and 12th day after digoxin administration.
resultsLA AEF, PEF, RF, KE, and Vcf were significantly lower in patients than in controls (p < 0.001). LA AEF, PEF, RF, KE, and Vcf increased significantly both in patients and controls after digoxin administration (p < 0.001). This increase was greater in patients than in controls (p < 0.001). KE was linearly correlated with LA volume at the onset of atrial systole in all participants. The slope and the intercept of this relation were significantly increased after digoxin both in patients and in controls (p < 0.001).
conclusionsLA performance is impaired in patients with heart failure. Dilated atria manifest atrial failure. Digoxin improves LA performance and LA contractility both in dilated and in normal atria. The effects of digoxin on LA contractility are augmented in the failing atria compared with the normal atria.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.