ArticleJournal of bacteriology2003
MtaR, a regulator of methionine transport, is critical for survival of group B streptococcus in vivo.
Article in Journal of bacteriology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 61 citations in OpenAlex.
- Eliminate pneumococcal colonization by targeting intracellular acidification that promotes H2O2 production to enhance bacterial survival.PLoS pathogens · 2026Article
- Identification of the methionine transporter MetQ in Streptococcus suis and its contribution to virulence and biofilm formation.Veterinary research · 2025Article
- Group B streptococcal infections in pregnancy and early life.Clinical microbiology reviews · 2025Review
- Glutamine enhances pneumococcal growth under methionine semi-starvation by elevating intracellular pH.Frontiers in microbiology · 2024Article
- Article
- Investigating the Antibacterial Properties of Prospective Scabicides.Biomedicines · 2022Article
- Transition of Serotype 35B Pneumococci From Commensal to Prevalent Virulent Strain in Children.Frontiers in cellular and infection microbiology · 2021Article
- An Enzyme Containing the Conserved Domain of Unknown Function DUF62 Acts as a Stereoselective (RChembiochem : a European journal of chemical biology · 2020Article
- Genome-Wide Assessment of Streptococcus agalactiae Genes Required for Survival in Human Whole Blood and Plasma.Infection and immunity · 2020Article
- Methionine Availability in the Arthropod Intestine Is Elucidated through Identification of Vibrio cholerae Methionine Acquisition Systems.Applied and environmental microbiology · 2020Article
- The Double Life of Group B Streptococcus: Asymptomatic Colonizer and Potent Pathogen.Journal of molecular biology · 2019Review
- Characterization of a Two-Component System Transcriptional Regulator, LtdR, That Impacts Group B Streptococcal Colonization and Disease.Infection and immunity · 2018Article
- A two-component signal transduction system contributes to the virulence ofJournal of veterinary science · 2018Article
- Transcriptome and Proteome of Fish-PathogenicFrontiers in microbiology · 2018Article
- Remodeling of the Streptococcus mutans proteome in response to LrgAB and external stresses.Scientific reports · 2017Article
- The Transcriptional Regulator CpsY Is Important for Innate Immune Evasion in Streptococcus pyogenes.Infection and immunity · 2017Article
- Methionine-mediated gene expression and characterization of the CmhR regulon inMicrobial genomics · 2016Article
- Control of Clostridium difficile Physiopathology in Response to Cysteine Availability.Infection and immunity · 2016Article
- Cysteine-Mediated Gene Expression and Characterization of the CmbR Regulon inFrontiers in microbiology · 2016Article
- Zebrafish as a model for zoonotic aquatic pathogens.Developmental and comparative immunology · 2014Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The group B streptococcus (GBS) is an important human pathogen that infects newborns as well as adults. GBS also provides a model system for studying adaptation to different host environments due to its ability to survive in a variety of sites within the host. In this study, we have characterized a transcription factor, MtaR, that is essential for the ability of GBS to survive in vivo. An isogenic strain bearing a kanamycin insertion in mtaR was attenuated for survival in a neonatal-rat model of sepsis. The mtaR mutant grew poorly in human plasma, suggesting that its utilization of plasma-derived nutrients was inefficient. When an excess of exogenous methionine (200 microg/ml) was provided to the mtaR mutant, its growth rate in plasma was restored to that of the wild-type strain. The mtaR mutant grew poorly in chemically defined medium (CDM) prepared with methionine at a concentration similar to that of plasma (4 microg/ml) but was able to grow normally in CDM prepared with a high concentration of methionine (400 microg/ml). Both the wild-type strain and the mtaR mutant were incapable of growth in CDM lacking methionine, indicating that GBS cannot synthesize methionine de novo. When the abilities of the strains to incorporate radiolabeled methionine were compared, the mtaR mutant incorporated fivefold less methionine than the wild-type strain during a 10-min period. Collectively, the results from this study suggest that the ability to regulate expression of a methionine transport system is critical for GBS survival in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.