ArticleThe Biochemical journal2004
Latrophilin is required for toxicity of black widow spider venom in Caenorhabditis elegans.
Article in The Biochemical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- The therapeutic potential of orphan adhesion G-protein-coupled receptors.Nature reviews. Drug discovery · 2026Review
- Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons.eLife · 2024Article
- Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons.bioRxiv : the preprint server for biology · 2024Article
- Venom biotechnology: casting light on nature's deadliest weapons using synthetic biology.Frontiers in bioengineering and biotechnology · 2023Review
- Animal toxins - Nature's evolutionary-refined toolkit for basic research and drug discovery.Biochemical pharmacology · 2020Review
- Nomenclature and Comparative Morphology of the Teneurin/TCAP/ADGRL Protein Families.Frontiers in neuroscience · 2019Review
- Latrophilins: A Neuro-Centric View of an Evolutionary Conserved Adhesion G Protein-Coupled Receptor Subfamily.Frontiers in neuroscience · 2019Article
- Article
- Review
- Toward a better understanding of ADHD: LPHN3 gene variants and the susceptibility to develop ADHD.Attention deficit and hyperactivity disorders · 2010Review
- The latrophilins, "split-personality" receptors.Advances in experimental medicine and biology · 2010Review
- Latrophilin signaling links anterior-posterior tissue polarity and oriented cell divisions in the C. elegans embryo.Developmental cell · 2009Article
- The putative cyclooctadepsipeptide receptor depsiphilin of the canine hookworm Ancylostoma caninum.Parasitology research · 2009Article
- Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology.Toxicological sciences : an official journal of the Society of Toxicology · 2008Review
- Solution structure and sugar-binding mechanism of mouse latrophilin-1 RBL: a 7TM receptor-attached lectin-like domain.Structure (London, England : 1993) · 2008Article
- alpha-Latrotoxin and its receptors.Handbook of experimental pharmacology · 2008Review
- Insecticidal toxins from black widow spider venom.Toxicon : official journal of the International Society on Toxinology · 2007Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Black widow spider venom (BWSV) kills Caenorhabditis elegans after injection owing to the presence of heat- and detergent-sensitive components, which are high-molecular-mass latrotoxins. A C. elegans homologue of latrophilin/CIRL (calcium-independent receptor for latrotoxin), B0457.1, was identified and shown to have five conserved domains. RNAi (RNA interference) of this gene rendered C. elegans resistant to BWSV, whereas RNAi for CYP37A1 or a neurexin I homologue, and a deletion mutant of the related B0286.2 gene, had no effect on BWSV toxicity. The latrophilin RNAi mutants exhibit changes in defaecation cycle and alterations in drug sensitivity. These results demonstrate that latrophilin mediates the toxicity of BWSV and provide evidence for a physiological function of this receptor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.