Evidence map›Paper›PMID 14594111›Full record

ArticleJournal of endocrinological investigation2003

The methylenetethrahydrofolate reductase (MTHFR) C677T polymorphism and male infertility in Italy.

L Stuppia, V Gatta, O Scarciolla, A Colosimo, P Guanciali-Franchi, G Calabrese, G Palka

Abstract read
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In one paragraph

Article in Journal of endocrinological investigation, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 8 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 8 syntheses or guidelines pooled it, 79 citations in OpenAlex.

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  15. Association of theBalkan journal of medical genetics : BJMG · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

L StuppiaDepartment of Biomedical Sciences, G. D'Annunzio University, Chieti, Italy.
V Gatta
O Scarciolla
A Colosimo
P Guanciali-Franchi
G Calabrese
G Palka
University of Chieti-Pescara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The 677T allele of the MTHFR gene has been suggested to represent a factor of risk for male infertility. In order to confirm this association, we investigated the presence of the 677T allele in 93 Italian infertile patients, selected after the exclusion of other possible genetic causes of infertility, and in 105 Italian fertile controls. The homozygous 677TT genotype was present in 20.4% of patients and 27.6% of controls. These results do not support an association between the MTHFR 677T allele and male infertility in Italy.

Indexed as

AdultHumansInfertility, MaleItalyMaleMethylenetetrahydrofolate Reductase (NADPH2)Middle AgedOligospermiaPolymorphism, GeneticSperm CountMethylenetetrahydrofolate Reductase (NADPH2)

Identifiers

PMID14594111
OpenAlexW1974249319

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.