ArticlePediatric nephrology (Berlin, Germany)2003
Implication of serum IgE in childhood nephrotic syndrome.
Article in Pediatric nephrology (Berlin, Germany), 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 24 citations in OpenAlex.
- Non-syndromic hyper-IgE in children: A practical approach.The World Allergy Organization journal · 2026Review
- Article
- An updated view of the pathogenesis of steroid-sensitive nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2022Review
- The clinicopathological features of patients with membranous nephropathy.International journal of nephrology and renovascular disease · 2018Article
- Risk of idiopathic nephrotic syndrome among children with asthma: a nationwide, population-based cohort study.Pediatric research · 2015Article
- Occurrence of common allergic diseases in children with idiopathic nephrotic syndrome.Journal of epidemiology · 2015Article
- Increased risk of idiopathic nephrotic syndrome in children with atopic dermatitis.Pediatric nephrology (Berlin, Germany) · 2014Article
- The clinical characteristics of steroid responsive nephrotic syndrome of children according to the serum immunoglobulin E levels and cytokines.Yonsei medical journal · 2012Article
- Idiopathic nephrotic syndrome and atopy: is there a common link?American journal of kidney diseases : the official journal of the National Kidney Foundation · 2009Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Elevated serum IgE levels have been related to glomerular diseases. We investigated the relationship between serum total and specific IgE levels and their modulating factors [interleukin-4 (IL-4) and sCD23] and the outcome of childhood nephrotic syndrome (NS) after steroid treatment. We found that children with NS had significantly higher serum IgE levels than age-matched allergic patients and normal controls. Patients with steroid-resistant nephrotic syndrome (SRNS) had higher serum IgE levels than patients with steroid-sensitive nephrotic syndrome (SSNS) both pre and post treatment. Elevated initial serum IgE levels appeared to be associated with poor outcome. Although one-half of nephrotic children had detectable specific IgE to common allergens (dust mites or milk), the presence of specific IgE was not correlated with disease outcome. Serum IL-4 levels were not different among normal controls and patients with SRNS or SSNS. However, serum sCD23 levels in NS patients were significantly higher than in normal controls both pre and post treatment. Serum sCD23, but not IL-4, levels were correlated with serum total IgE levels. Our results suggest that regulation of total IgE production correlates with the disease activity and outcome of NS, although the presence of common specific IgE may not be linked to the pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.