ArticleDevelopment genes and evolution2003
Characterization of hey bHLH genes in teleost fish.
Article in Development genes and evolution, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- Species-specific roles of the Notch ligands, receptors, and targets orchestrating the signaling landscape of the segmentation clock.Frontiers in cell and developmental biology · 2023Review
- The vertebrate Embryo Clock: Common players dancing to a different beat.Frontiers in cell and developmental biology · 2022Review
- Neural stem cell quiescence and stemness are molecularly distinct outputs of the Notch3 signalling cascade in the vertebrate adult brain.Development (Cambridge, England) · 2018Article
- Nkx genes are essential for maintenance of ventricular identity.Development (Cambridge, England) · 2013Article
- Article
- Comparative and evolutionary analysis of the HES/HEY gene family reveal exon/intron loss and teleost specific duplication events.PloS one · 2012Article
- prdm1a Regulates sox10 and islet1 in the development of neural crest and Rohon-Beard sensory neurons.Genesis (New York, N.Y. : 2000) · 2010Article
- Hey bHLH factors in cardiovascular development.Pediatric cardiology · 2010Review
- Kaposi's sarcoma-associated herpesvirus RTA promotes degradation of the Hey1 repressor protein through the ubiquitin proteasome pathway.Journal of virology · 2009Article
- Vertebrate heart growth is regulated by functional antagonism between Gridlock and Gata5.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Jagged2a-notch signaling mediates cell fate choice in the zebrafish pronephric duct.PLoS genetics · 2007Article
- Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors.Nucleic acids research · 2007Review
- her11 is involved in the somitogenesis clock in zebrafish.Development genes and evolution · 2004Article
- The Notch target genes Hey1 and Hey2 are required for embryonic vascular development.Genes & development · 2004Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hairy-related basic helix-loop-helix (bHLH) transcription factors are targets of Delta-Notch signaling and represent essential components for a number of cell fate decisions during vertebrate embryogenesis. Hey genes encode a subfamily of hairy-related proteins that have been implicated in processes like somitogenesis, blood vessel and heart development. We have identified and characterized hey genes in three teleost fish lineages using degenerate PCR and database searches. Phylogenetic analysis of Hey proteins suggests a complex pattern of evolution with high divergence of hey2 in Takifugu rubripes (Fugu, Japanese pufferfish) and possibly loss in the related Tetraodon nigroviridis (the freshwater pufferfish). In addition, duplication of hey1 in both pufferfishes, Fugu and Tetraodon, was observed. Conversely, zebrafish (Danio rerio) has the same complement of three hey genes as known from mammals. All three hey genes show much more restricted gene expression profiles in zebrafish when compared to mouse. Importantly, while all three murine Hey genes are expressed in overlapping patterns in the presomitic mesoderm (PSM) and somites, in zebrafish only hey1 shows PSM and somite expression in a highly dynamic fashion. Therefore, while overlapping expression might account for redundancy of hey function in higher vertebrates, this is unlikely to be the case in zebrafish. In deltaD (dlD) deficient after-eight zebrafish mutants, the dynamic expression of hey1 in the PSM is impaired and completely lost in newly formed somitomeres. Overexpression of dlD on the other hand results in the ectopic expression of hey1 in the axial mesoderm. Hence, hey1 represents a target of Delta-Notch signaling dynamically expressed during somite formation in zebrafish.
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