ReviewEMBO reports2003
RNA sensors: novel regulators of gene expression.
Review in EMBO reports, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 67 citations in OpenAlex.
- Programmed -1 ribosomal frameshifting in SARS-CoV-2: molecular mechanisms and implications for antiviral targeting.Virus genes · 2026Review
- Molecular features and expression kinetics of interleukin-10 gene from the marine teleost, Snubnose pompano (Trachinotus blochii).Molecular biology reports · 2024Article
- All-trans retinoic acid changes muscle fiber type via increasing GADD34 dependent on MAPK signal.Life science alliance · 2022Article
- Computational based design and tracking of synthetic variants of Porcine circovirus reveal relations between silent genomic information and viral fitness.Scientific reports · 2021Article
- RNA polymerase III and antiviral innate immune response.Transcription · 2021Review
- Shaping the regulation of the p53 mRNA tumour suppressor: the co-evolution of genetic signatures.BMC cancer · 2019Review
- Elevated intracellular cAMP exacerbates vulnerability to oxidative stress in optic nerve head astrocytes.Cell death & disease · 2018Article
- Design of Artificial Riboswitches as Biosensors.Sensors (Basel, Switzerland) · 2017Review
- Gene therapy for bone engineering.Frontiers in bioengineering and biotechnology · 2015Review
- Regulatory RNAs: charming gene management styles for synthetic biology applications.RNA biology · 2013Review
- Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation.Nucleic acids research · 2010Article
- Dynamic refolding of IFN-gamma mRNA enables it to function as PKR activator and translation template.Nature chemical biology · 2009Article
- Molecular processes in biological thermosensation.Journal of biophysics (Hindawi Publishing Corporation : Online) · 2008Article
- Thermosensors in eubacteria: role and evolution.Journal of biosciences · 2007Review
- Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action.Microbiology and molecular biology reviews : MMBR · 2006Review
- DNA methylation, riboswitches, and transcription factor activity: fundamental mechanisms of gene-nutrient interactions involving vitamins.Molecular biology reports · 2006Review
- Searching for IRES.RNA (New York, N.Y.) · 2006Review
- Molecular basis for temperature sensing by an RNA thermometer.The EMBO journal · 2006Article
- Recent progress in the battle between oncolytic viruses and tumours.Nature reviews. Cancer · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA-mediated control can evolve far more rapidly than mechanisms that rely on proteins, creating selective advantages in adaptive gene regulation. Recently, evidence has emerged that messenger RNA is a source of cis-acting RNA elements that sense external signals and thereby regulate gene expression. With exquisite specificity, metabolite-sensing riboswitches control the formation or translation of prokaryotic mRNA. In eukaryotes, RNA sensors in human antiviral cytokine genes that encode tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) have been shown to activate strongly the RNA-dependent protein kinase PKR, a stress kinase that is also activated by double-stranded RNA--a hallmark of viral infection. These cis-acting RNA elements in the TNF-alpha and IFN-gamma transcripts function as sensors of intracellular PKR levels and regulate gene expression at the level of mRNA splicing and translation, respectively. Although RNA sensors in bacteria may be remnants of an ancient RNA world, it is likely that they form an integral part of higher eukaryotic genomes as well.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.