ArticleMolecular psychiatry2003
M129V variation in the prion protein may influence cognitive performance.
Article in Molecular psychiatry, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 41 citations in OpenAlex.
- Prion protein codon 129 polymorphism in mild cognitive impairment and dementia: the Rotterdam Study.Brain communications · 2020Article
- Alzheimer's disease and prion protein.Intractable & rare diseases research · 2013Review
- Between destiny and disease: genetics and molecular pathways of human central nervous system aging.Progress in neurobiology · 2011Review
- The impact of genetic research on our understanding of normal cognitive ageing: 1995 to 2009.Neuropsychology review · 2009Review
- The forthcoming revision of the diagnostic and classificatory system: perspectives based on the European psychiatric tradition.European archives of psychiatry and clinical neuroscience · 2008Review
- Systematic of psychiatric disorders between categorical and dimensional approaches: Kraepelin's dichotomy and beyond.European archives of psychiatry and clinical neuroscience · 2008Review
- The assessment of cognitive impairment would be a relevant addition to the criteria for diagnosing schizophrenia.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2008Article
- A linkage and family-based association analysis of a potential neurocognitive endophenotype of bipolar disorder.Neuromolecular medicine · 2007Article
- The prion protein M129V polymorphism: longevity and cognitive impairment among Polish centenarians.PrionArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Correlations between general intelligence (g) and brain volume are about 0.40, and the correlation between g and white matter volume has been reported to be largely due to genetic factors. Establishing that the correlation between brain volumes and cognitive abilities is mediated by shared genetic factors is only the first step in unveiling the relation between them. We have recently shown that methionine at codon 129 in the prion protein is associated with white matter reduction in a group of healthy volunteers and schizophrenic patients. The present study examines the influence of the same genetic variation on psychometric cognitive performance measurements in 335 community-based healthy volunteers. The polymorphism was associated with Full Scale IQ (genotype: F=4.38, df=2/317, P=0.013; allele: F=8.04, df=1/658, P=0.005), as measured by HAWIE-R (German version of the Wechsler Adult Intelligence Scale, Revised). Genotype accounted for 2.7% of the total variability in Full Scale IQ (partial eta2=0.027). An exploratory analysis revealed association with several HAWIE-R subscales; the association with the Digit Symbol subtest remained significant after correction for multiple testing. In summary, we deliver evidence for an association of a common genetic variation in the prion protein gene with cognitive performance. However, independent replications are needed before firm conclusions can be drawn.
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