ArticleJournal of molecular neuroscience : MN2003
Neuregulin-1 isoforms are differentially expressed in the intact and regenerating adult rat nervous system.
Article in Journal of molecular neuroscience : MN, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 54 citations in OpenAlex.
- Review
- Engineering the Future of Restorative Clinical Peripheral Nerve Surgery.Advanced healthcare materials · 2025Review
- Pleiotrophin-Neuregulin1 promote axon regeneration and sorting in conduit repair of critical nerve gap injuries.Research square · 2023Article
- Type III NRG-1 plays a regulatory role in the regeneration process of nerves from the beginning of transplantation.Journal of orthopaedic surgery and research · 2023Article
- Genetic labeling reveals spatial and cellular expression pattern of neuregulin 1 in mouse brain.Cell & bioscience · 2023Article
- Cartilage regeneration in zebrafish depends on Nrg1/ErbB signaling pathway.Frontiers in cell and developmental biology · 2023Article
- RNA Binding Motif 5 (RBM5) in the CNS-Moving Beyond Cancer to Harness RNA Splicing to Mitigate the Consequences of Brain Injury.Frontiers in molecular neuroscience · 2020Article
- NMDAR Hypofunction Animal Models of Schizophrenia.Frontiers in molecular neuroscience · 2019Review
- Neuregulin 1-ErbB module in C-bouton synapses on somatic motor neurons: molecular compartmentation and response to peripheral nerve injury.Scientific reports · 2017Article
- Glutamate-dependent ectodomain shedding of neuregulin-1 type II precursors in rat forebrain neurons.PloS one · 2017Article
- Neurological dysfunctions associated with altered BACE1-dependent Neuregulin-1 signaling.Journal of neurochemistry · 2016Review
- Neuregulin 1 signalling modulates mGluR1 function in mesencephalic dopaminergic neurons.Molecular psychiatry · 2015Article
- Regulation of alternative VEGF-A mRNA splicing is a therapeutic target for analgesia.Neurobiology of disease · 2014Article
- Astrocyte-like cells derived from human oral mucosa stem cells provide neuroprotection in vitro and in vivo.Stem cells translational medicine · 2014Article
- Neuronal merlin influences ERBB2 receptor expression on Schwann cells through neuregulin 1 type III signalling.Brain : a journal of neurology · 2014Article
- Transgenic overexpression of the type I isoform of neuregulin 1 affects working memory and hippocampal oscillations but not long-term potentiation.Cerebral cortex (New York, N.Y. : 1991) · 2012Article
- The role of neuregulin-1 in the response to nerve injury.Future neurology · 2011Article
- Specific regulation of NRG1 isoform expression by neuronal activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Neuregulin-1 at synapses on phrenic motoneurons.The Journal of comparative neurology · 2010Article
- Injury modality, survival interval, and sample region are critical determinants of qRT-PCR reference gene selection during long-term recovery from brain trauma.Journal of neurotrauma · 2009Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our knowledge on Neuregulin-1 (Nrg-1) during development of the nervous system is increasing rapidly, but little is known about Nrg-1-ErbB signaling in the adult brain. Nrg-1 is involved in determination, proliferation, differentiation, and migration of neurons and glial cells in the developing brain. In the peripheral nervous system, Nrg-1 signaling is required for Schwann cell differentiation and myelination, and establishment of neuromuscular junctions (NMJs). Multiple alternative splicing of Nrg-1 was shown, but correlation of its structural and functional diversity was rarely addressed. Therefore, we investigated the expression of Nrg-1 isoforms in the rat brain and brain-derived cell types, and their involvement in regeneration of the adult brain, using immunohistochemistry, in situ hybridization, and semiquantitative RT-PCR. We found expression of at least 12 distinct Nrg-1 isoforms in the brain and altered expression of several isoforms in the facial motor nucleus after peripheral transection of the seventh cranial nerve. An upregulation of Nrg-1 type-I mRNA, probably type- I-alpha, was observed in reactive astrocytes of the facial nucleus 1 d postaxotomy. Nrg-1 type-III and the splice variants beta1 and beta5 are dramatically downregulated in axotomized motoneurons, which lack contact to their target tissue. Baseline expression levels were reestablished when the first axons reached the facial muscles and reformed NMJs. Nrg-1-beta1 and -beta5 might act in maintenance of NMJs. The splice variants beta2 and beta4 display an initial downregulation of mRNA levels, followed by an increase during the period of axon remyelination. Thus, Nrg- 1-beta2 and -beta4 might be involved in myelination.
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