ArticleProceedings of the National Academy of Sciences of the United States of America2003
Extensive repetitive DNA facilitates prokaryotic genome plasticity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.
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Who cites it
70 citing papers in PubMed, 1 synthesis or guideline pooled it, 138 citations in OpenAlex.
- Pooled it
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- Diversification in ANME-1 archaea is associated with the presence of highly variable genomic hotspots.Nature communications · 2026Article
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- Alternative nucleic acid structures in microbial biology: regulatory functions and antimicrobial opportunities.Frontiers in cellular and infection microbiology · 2026Review
- Exploring genetic diversity and genomic insights of Bacillus subtilis isolates from cassava rhizosphere using molecular barcoding and whole genome sequencing.Scientific reports · 2025Article
- Overcoming antibiotic-resistantWorld journal of gastroenterology · 2025Review
- The role of gut microbiota in insulin resistance: recent progress.Frontiers in microbiology · 2025Review
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- Structural and functional diversity of type IV secretion systems.Nature reviews. Microbiology · 2024Review
- A synthetic synthesis to explore animal evolution and development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- CRISPR-Cas-mediated gene editing in lactic acid bacteria.Molecular biology reports · 2020Review
- "Gene accordions" cause genotypic and phenotypic heterogeneity in clonal populations of Staphylococcus aureus.Nature communications · 2020Article
- Repetitive DNA profile of the amphibian mitogenome.BMC bioinformatics · 2020Article
- A new statistic for efficient detection of repetitive sequences.Bioinformatics (Oxford, England) · 2019Article
- α-Difluoromethylornithine reduces gastric carcinogenesis by causing mutations inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- The variome of pneumococcal virulence factors and regulators.BMC genomics · 2018Article
- Molecular basis for the functions of a bacterial MutS2 in DNA repair and recombination.DNA repair · 2017Article
- Dynamic Expansion and Contraction ofmBio · 2017Article
10 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Prokaryotic genomes are substantially diverse, even when from closely related species, with the resulting phenotypic diversity representing a repertoire of adaptations to specific constraints. Within the microbial population, genome content may not be fixed, as changing selective forces favor particular phenotypes; however, organisms well adapted to particular niches may have evolved mechanisms to facilitate such plasticity. The highly diverse Helicobacter pylori is a model for studying genome plasticity in the colonization of individual hosts. For H. pylori, neither point mutation, nor intergenic recombination requiring the presence of multiple colonizing strains, is sufficient to fully explain the observed diversity. Here we demonstrate that H. pylori has extensive, nonrandomly distributed repetitive chromosomal sequences, and that recombination between identical repeats contributes to the variation within individual hosts. That H. pylori is representative of prokaryotes, especially those with smaller (<2 megabases) genomes, that have similarly extensive direct repeats, suggests that recombination between such direct DNA repeats is a widely conserved mechanism to promote genome diversification.
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