ArticleMolecular biology of the cell2003
Receptor internalization in yeast requires the Tor2-Rho1 signaling pathway.
Article in Molecular biology of the cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Heterozygous Mutations in Aromatic Amino Acid Synthesis Genes Trigger TOR Pathway Activation inmicroPublication biology · 2022Article
- Integrins in disguise - mechanosensors inMicrobial cell (Graz, Austria) · 2019Review
- TORC2 controls endocytosis through plasma membrane tension.The Journal of cell biology · 2019Article
- CAP-Gly proteins contribute to microtubule-dependent trafficking via interactions with the C-terminal aromatic residue of α-tubulin.Small GTPases · 2019Review
- Chemogenomic profiling to understand the antifungal action of a bioactive aurone compound.PloS one · 2019Article
- Target of rapamycin complex 2-dependent phosphorylation of the coat protein Pan1 by Akl1 controls endocytosis dynamics inThe Journal of biological chemistry · 2018Article
- Heterologous mammalian Akt disrupts plasma membrane homeostasis by taking over TORC2 signaling in Saccharomyces cerevisiae.Scientific reports · 2018Article
- A Flow Cytometry-Based Phenotypic Screen To Identify Novel Endocytic Factors inG3 (Bethesda, Md.) · 2018Article
- Functional Genomic Analysis of Candida albicans Adherence Reveals a Key Role for the Arp2/3 Complex in Cell Wall Remodelling and Biofilm Formation.PLoS genetics · 2016Article
- A role for the yeast CLIP170 ortholog, the plus-end-tracking protein Bik1, and the Rho1 GTPase in Snc1 trafficking.Journal of cell science · 2016Article
- Inhibition of autophagy contributes to the toxicity of cadmium telluride quantum dots in Saccharomyces cerevisiae.International journal of nanomedicine · 2016Article
- Rho1- and Pkc1-dependent phosphorylation of the F-BAR protein Syp1 contributes to septin ring assembly.Molecular biology of the cell · 2015Article
- Target of Rapamycin Complex 2 Regulates Actin Polarization and Endocytosis via Multiple Pathways.The Journal of biological chemistry · 2015Article
- TORC2 and eisosomes are spatially interdependent, requiring optimal level of phosphatidylinositol 4, 5-bisphosphate for their integrity.Journal of biosciences · 2015Article
- Actin and endocytosis in budding yeast.Genetics · 2015Review
- TOR complex 2-Ypk1 signaling regulates actin polarization via reactive oxygen species.Molecular biology of the cell · 2014Article
- Calcineurin determines toxic versus beneficial responses to α-synuclein.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Role of turgor pressure in endocytosis in fission yeast.Molecular biology of the cell · 2014Article
- Inactivation of Tor proteins affects the dynamics of endocytic proteins in early stage of endocytosis.Journal of biosciences · 2013Article
- Rhb1 regulates the expression of secreted aspartic protease 2 through the TOR signaling pathway in Candida albicans.Eukaryotic cell · 2012Article
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Authors and funding
5 authors.
Funding
Abstract
Efficient internalization of proteins from the cell surface is essential for regulating cell growth and differentiation. In a screen for yeast mutants defective in ligand-stimulated internalization of the alpha-factor receptor, we identified a mutant allele of TOR2, tor2G2128R. Tor proteins are known to function in translation initiation and nutrient sensing and are required for cell cycle progression through G1. Yeast Tor2 has an additional role in regulating the integrity of the cell wall by activating the Rho1 guanine nucleotide exchange factor Rom2. The endocytic defect in tor2G2128R cells is due to disruption of this Tor2 unique function. Other proteins important for cell integrity, Rom2 and the cell integrity sensor Wsc1, are also required for efficient endocytosis. A rho1 mutant specifically defective in activation of the glucan synthase Fks1/2 does not internalize alpha-factor efficiently, and fks1Delta cells exhibit a similar phenotype. Removal of the cell wall does not inhibit internalization, suggesting that the function of Rho1 and Fks1 in endocytosis is not through cell wall synthesis or structural integrity. These findings reveal a novel function for the Tor2-Rho1 pathway in controlling endocytosis in yeast, a function that is mediated in part through the plasma membrane protein Fks1.
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