ArticlePflugers Archiv : European journal of physiology2003
Mechanism of the positive contractile effect of nitric oxide on rat ventricular cardiomyocytes with positive force/frequency relationship.
Article in Pflugers Archiv : European journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 43 citations in OpenAlex.
- Asymmetric dimethylarginine (ADMA) modulates frequency-dependent muscarinic antagonism of β-adrenergic regulation of rat papillary muscle contractility.Research square · 2026Article
- A common gene signature of the right ventricle in failing rat and human hearts.Nature cardiovascular research · 2024Article
- Monoamine Oxidase A Contributes to Serotonin-But Not Norepinephrine-Dependent Damage of Rat Ventricular Myocytes.Biomolecules · 2023Article
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- Lack of Contribution of p66shc to Pressure Overload-Induced Right Heart Hypertrophy.International journal of molecular sciences · 2020Article
- Autocrine effects of PCSK9 on cardiomyocytes.Basic research in cardiology · 2020Article
- Ischaemic post-conditioning in rats: Responder and non-responder differ in transcriptome of mitochondrial proteins.Journal of cellular and molecular medicine · 2020Article
- Alterations in Glucose Metabolism During the Transition to Heart Failure: The Contribution of UCP-2.Cells · 2020Article
- Protection against pressure overload-induced right heart failure by uncoupling protein 2 silencing.Cardiovascular research · 2019Article
- JDP2 overexpression provokes cardiac dysfunction in mice.Scientific reports · 2018Article
- Oxidized low-density lipoprotein (oxLDL) affects load-free cell shortening of cardiomyocytes in a proprotein convertase subtilisin/kexin 9 (PCSK9)-dependent way.Basic research in cardiology · 2017Article
- Mechanisms by which calcium receptor stimulation modifies electromechanical coupling in isolated ventricular cardiomyocytes.Pflugers Archiv : European journal of physiology · 2015Article
- The concomitant coronary vasodilator and positive inotropic actions of the nitroxyl donor Angeli's salt in the intact rat heart: contribution of soluble guanylyl cyclase-dependent and -independent mechanisms.British journal of pharmacology · 2014Article
- Effects of echinocandin preparations on adult rat ventricular cardiomyocytes. Preliminary results of an in vitro study.Der Anaesthesist · 2014Article
- Rat intermedin1-47 does not improve functional recovery in postischemic hearts.Naunyn-Schmiedeberg's archives of pharmacology · 2011Article
- Transforming growth factor β₁ oppositely regulates the hypertrophic and contractile response to β-adrenergic stimulation in the heart.PloS one · 2011Article
- Phosphodiesterase 5 restricts NOS3/Soluble guanylate cyclase signaling to L-type Ca2+ current in cardiac myocytes.Journal of molecular and cellular cardiology · 2009Article
- Enhanced SERCA2A expression improves contractile performance of ventricular cardiomyocytes of rat under adrenergic stimulation.Pflugers Archiv : European journal of physiology · 2008Article
- Treprostinil potentiates the positive inotropic effect of catecholamines in adult rat ventricular cardiomyocytes.British journal of pharmacology · 2007Article
- Positive inotropic effects of carbon monoxide-releasing molecules (CO-RMs) in the isolated perfused rat heart.British journal of pharmacology · 2006Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The positive contractile effect of nitric oxide (NO) donors was studied on isolated rat ventricular cardiomyocytes within a range of a positive force/frequency relationship. We determined whether the observed effect depended on cGMP. The NO donors S-nitroso-acetyl-D,L-penicillamine (SNAP) and N-[4-[1-(3-aminopropyl)-2-hydroxy-2-nitrosohydrazino]butyl]-1,3-propanediamine (spermine-NONO) increased contractile responsiveness transiently in a concentration- and frequency-dependent manner. The influence of NO donors on cGMP levels was enhanced under beating conditions. The positive contractile effect of NO donors was inhibited by adenosine 3',5'-cyclic monophosphothioate Rp diastereomer (Rp-cAMPS), but not by bisindolylmaleimide. Inhibition of the soluble guanylyl cyclase (sGC) by 1 H-[1,2,4]-oxadiazole-[4,3-a]-quinoxalin-1-one (ODQ) inhibited the positive contractile effect of NO donors. Direct activation of sGC by 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole (YC1) or addition of 8-bromo cGMP increased cell contractility comparably to NO donors. Inhibition of G(alphas) proteins by NF441 inhibited the positive contractile effect of NO donors. In contrast, NO donors did not potentiate the positive contractile effect of forskolin. These results demonstrate that the positive contractile effect of NO donors on rat ventricular cardiomyocytes working in a range of a positive force/frequency relationships is enhanced. It is mediated by NO-dependent stimulation of the sGC interacting with G(alphas) proteins.
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