Trial reportEuropean journal of applied physiology2004
Effect of low oxygen inhalation on changes in blood pH, lactate, and ammonia due to exercise.
Trial report in European journal of applied physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 17 citations in OpenAlex.
- Changes in acid-base and ion balance during exercise in normoxia and normobaric hypoxia.European journal of applied physiology · 2017Trial
- Effect of hypercapnia on changes in blood pH, plasma lactate and ammonia due to exercise.European journal of applied physiology · 2005Trial
- The Effect of 4 Weeks Fixed and Mixed Intermittent Hypoxic Training (IHT) on Respiratory Metabolic and Acid-base Response of Capillary Blood During Submaximal Bicycle Exercise in Male Elite Taekwondo Players.Journal of exercise nutrition & biochemistry · 2016Article
- Influence of acute normobaric hypoxia on physiological variables and lactate turn point determination in trained men.Journal of sports science & medicine · 2014Article
- Effects of acute moderate hypoxia on anaerobic capacity in endurance-trained runners.European journal of applied physiology · 2007Article
- The influence of acute and 23 days of intermittent hypoxic exposures on the exercise-induced forehead sweating response.European journal of applied physiology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study examined the effect of hypoxia-induced respiratory alkalosis on exercise-induced metabolic acidosis and increases in plasma lactate and ammonia levels. Six male subjects underwent exercise of increasing intensity until exhaustion: (1) in normoxia (20.9% O(2)) (=MAX), (2) in hypoxia (12% O(2)) (=HP) in which hypoxic condition had been maintained from 60 min before to 30 min after exercise, and (3) the same intensity of exercise as HP in normoxia (=SUB). Arterialized blood was drawn from a superficial vein. Post-exercise blood pH was significantly higher in HP than in MAX ( P<0.05), although plasma lactate was at the same level. For hypoxia as compared to normoxia, regression analysis confirmed a parallel shift of plasma lactate to higher pH levels indicating the effect of respiratory alkalosis ( P<0.01). After exercise plasma levels of ammonia were lower in HP than in MAX ( P<0.05). Regression analysis between ammonia and pH revealed nearly identical changes in hypoxia and normoxia at low pH. From these results, we conclude that: (1) hypoxia-induced respiratory alkalosis attenuated exhaustive exercise-induced metabolic acidosis, (2) plasma lactate concentration was determined by the relative exercise intensity, (3) the maximum plasma ammonia concentration under exhaustive exercise was reduced at hypoxia because of respiratory alkalosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.