ArticleRheumatology international2005
Serum homocysteine level is higher in Behçet's disease with vascular involvement.
Article in Rheumatology international, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 49 citations in OpenAlex.
- Serum Vitamin B12, Homocysteine and Methylmalonic Acid Levels in Patients With Parenchymal Neuro-Behçet's Syndrome.Archives of rheumatology · 2017Article
- Evaluation of Serum Homocysteine and Leptin Levels in Patients with Uveitis.Turkish journal of ophthalmology · 2015Article
- A case of Hughes-Stovin syndrome associated with hyperhomocysteinemia.Clinical rheumatology · 2010Article
- Hyperhomocysteinaemia in Behçet's Disease.Biochemistry research international · 2010Article
- Homocysteine levels in patients with Behçet's disease and patients with recurrent aphthous stomatitis.Clinical rheumatology · 2009Article
- Thymidylate synthase genotype and serum concentrations of homocysteine and folate in Behçet's disease.Clinical rheumatology · 2008Article
- Homocysteine may involve in the pathogenesis of Behcet's disease by inducing inflammation.Mediators of inflammation · 2008Article
- An unusual case of Behçet's disease presenting with postpartum ovarian iliac vein thrombosis and pulmonary embolism.Thrombosis journal · 2006Article
- 5,10-Methylenetetrahydrofolate reductase C677T gene polymorphism in Behcet's patients with or without ocular involvement.The British journal of ophthalmology · 2005Article
- Intracardiac thrombus in Behçet's disease: two case reports.Thrombosis journal · 2005Article
- Assessment of serum homocysteine, endothelin-1, and nitric oxide levels in behçet's disease.Indian journal of dermatologyArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveBehçet's disease (BD) is a multisystemic inflammatory disorder of unknown etiology that is sometimes associated with thrombosis. However, the mechanism of hypercoagulability is not known. In this study, we investigated whether hyperhomocysteinemia, being a well-known risk factor for thrombosis, is also a contributing risk factor to venous and arterial thromboses of BD.
methodsForty-five patients with BD and 40 healthy subjects were included in the study. Sixteen patients had vascular involvement. Serum homocysteine levels were determined by fluorescence polarization immunoassay.
resultsIn male patients, the frequency of vascular involvement was significantly higher than in females (46.7% vs 13.3%, P < 0.05). Serum homocysteine levels were significantly higher in patients with BD than healthy controls (P < 0.01), in patients with vascular involvement than those with mucocutaneous involvement (P < 0.01) and healthy controls (P = 0.001), and in male patients than in female patients (P < 0.001). There was no significant difference in homocysteine levels between the BD patients with mucocutaneous involvement and healthy subjects. In multiple regression analysis, serum homocysteine level was independently associated with thrombosis (odds ratio 1.29, P < 0.01), but male sex was not.
conclusionsThis preliminary study suggests that elevated serum homocysteine levels may play some role in the development of venous and arterial thromboses in BD.
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