ArticleEuropean biophysics journal : EBJ2004
Modulation of HERG channel inactivation by external cations.
Article in European biophysics journal : EBJ, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- Effects of Antiarrhythmic Drugs on hERG Gating in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes From a Patient With Short QT Syndrome Type 1.Frontiers in pharmacology · 2021Article
- KNeuroscience · 2020Article
- Role of the activation gate in determining the extracellular potassium dependency of block of HERG by trapped drugs.Channels (Austin, Tex.) · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the effect of external cations on the permeability characteristics and gating kinetics of the human ether- à- go- go-related gene (HERG) current using the whole-cell patch-clamp technique. Inward HERG currents were recorded on hyperpolarization in 140 mM external Cs(+) and Rb(+), as well as K(+). The permeability ratios of Rb(+) and Cs(+) relative to K(+) were 1.25 and 0.56, respectively. Biphasic outward currents were recorded on depolarization in 140 mM Cs(+) and in Rb(+ )with much smaller amplitude. The voltage dependence of inactivation was affected by external cations, such that the half-inactivation voltage shifted from -69.4+/-3.7 mV in K(+) to -30.7+/-1.6 mV in Cs(+) and to -35.8+/-1.9 mV in Rb(+) ( n=5). The time constants of inactivation were also changed significantly by external cations; tau of inactivation at +40 mV was 16.4+/-2.2 ms in 140 mM K(+), 181+/-20.3 ms in Cs(+), and 94.1+/-7.6 ms in Rb(+) ( n=5). Voltage dependence of activation was not altered significantly. The inhibition of the rapid inactivation mechanism by large cations may suggest that the "foot-in-the-door" model of gating is involved in HERG channel inactivation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.