Trial reportIntensive care medicine2004
Pharmacokinetics and pharmacodynamics of dopamine and norepinephrine in critically ill head-injured patients.
Trial report in Intensive care medicine, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 54 citations in OpenAlex.
- Continuous cerebral autoregulation monitoring by improved cross-correlation analysis: comparison with the cuff deflation test.Intensive care medicine · 2007Trial
- Effect of Weight-based versus Absolute Norepinephrine Dosing on Mortality Risk in Obese Patients with Septic Shock: An Observational, Multicohort, Retrospective Study.Anesthesiology · 2026Observational
- Personalized pulse wave propagation modeling to improve vasopressor dosing management in patients with severe traumatic brain injury.PLoS computational biology · 2025Article
- Implementation and Evaluation of Weight-Based Vasopressors in Intensive Care Units.The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2024Article
- The Impact of Inotropes and Vasopressors on Cerebral Oxygenation in Patients with Traumatic Brain Injury and Subarachnoid Hemorrhage: A Narrative Review.Brain sciences · 2024Review
- Evaluation of Dose Requirements Using Weight-Based versus Non-Weight-Based Dosing of Norepinephrine to Achieve a Goal Mean Arterial Pressure in Patients with Septic Shock.Journal of clinical medicine · 2023Article
- Effect of noradrenaline on propofol-induced mitochondrial dysfunction in human skeletal muscle cells.Intensive care medicine experimental · 2022Article
- Drug dosing in the critically ill obese patient: a focus on medications for hemodynamic support and prophylaxis.Critical care (London, England) · 2021Review
- Reduced Rank Least Squares for Real-Time Short Term Estimation of Mean Arterial Blood Pressure in Septic Patients Receiving Norepinephrine.IEEE journal of translational engineering in health and medicine · 2019Article
- Comparing the Rates of Dopamine Hemodynamic Effect Onset after Infusion through Peripheral Veins in Three Regions.Korean journal of critical care medicine · 2017Article
- Population pharmacokinetics and haemodynamic effects of norepinephrine in hypotensive critically ill children.British journal of clinical pharmacology · 2014Article
- A systematic review on pharmacokinetic changes in critically ill patients: role of extracorporeal membrane oxygenation.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2011Article
- A tool predicting future mean arterial blood pressure values improves the titration of vasoactive drugs.Journal of clinical monitoring and computing · 2010Article
- Epinephrine kinetics in septic shock--a means to understand variable catecholamine efficiency?Critical care (London, England) · 2009Article
- In vitro norepinephrine significantly activates isolated platelets from healthy volunteers and critically ill patients following severe traumatic brain injury.Critical care (London, England) · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo explore the pharmacokinetics and pharmacodynamics of dopamine and norepinephrine.
designProspective, controlled, trial.
settingNeurosciences critical care unit. PATIENTS: Eight patients with a head injury, requiring dopamine or norepinephrine infusions to support cerebral perfusion pressure (CPP).
interventionPatients received in randomised order, either dopamine or norepinephrine to achieve and maintain a CPP of 70 mmHg, and then, following a 30-min period of stable haemodynamics, a CPP of 90 mmHg. Data were then acquired using the second agent. Haemodynamic measurements were made during each period and a blood sample was obtained at the end of each study period for analysis of plasma catecholamine concentrations MEASUREMENTS AND
resultsPlasma levels of norepinephrine and dopamine were significantly related to infusion rates but did not have a simple linear relationship to haemodynamic parameters. However, there was a significant quadratic relationship between the infusion rate of dopamine and cardiac index (r2=0.431), and systemic vascular resistance index (r2=0.605), with a breakpoint (at which cardiac index reduced and SVRI increased) at a dopamine plasma level of approximately 50 nM/l (corresponding to an infusion rate of approximately 15 microg.kg(-1).min(-1)).
conclusionsNorepinephrine and dopamine have predictable pharmacokinetics; however, those of dopamine do not fit a simple first-order kinetic model. The pharmacodynamic effects of dopamine and norepinephrine show much inter-individual variability and unpredictability. Plasma levels of dopamine appear to relate to variations in adrenergic receptor effects with break points that reflect expectations from infusion-rate related pharmacodynamics.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.