Evidence map›Paper›PMID 14586071›Full record

ArticleEndocrine pathology2003

Immunohistochemical evaluation of vasopressin expression in breast fibrocystic disease and ductal carcinoma in situ (DCIS).

William G North, Wendy Wells, Michael J Fay, Rennie S Mathew, Edward M Donnelly, Vincent A Memoli

Abstract read
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In one paragraph

Article in Endocrine pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

William G NorthDepartment of Physiology, Dartmouth Medical School, Lebanon, NH 03756-0001, USA. william.north@dartmouth.edu
Wendy Wells
Michael J Fay
Rennie S Mathew
Edward M Donnelly
Vincent A Memoli
Dartmouth College · US

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Steven D Leach · 1985 to 2026
$91.3M
THE ROLE OF HORMONES IN HEALTH AND DISEASET32DK007508 · NIDDK · DARTMOUTH COLLEGE · PI NORTH, WILLIAM G · 1986 to 2011
$2.5M
NEUROPEPTIDES AND SMALL CELL CARCINOMAR01CA019613 · NCI · DARTMOUTH COLLEGE · PI NORTH, WILLIAM G · 1987 to 2002
$865k
NCI NIH HHS CA 19613NCI NIH HHS CA 23108NIDDK NIH HHS DK 07508NIDDK NIH HHS T32 DK007508
6 · The paper itself

Abstract

We previously found that expression of the vasopressin gene is a common feature of human breast cancer. In the present study we first examined 21 different cases of benign fibrocystic breast disease for vasopressin expression using immunohistochemistry and antibodies directed against vasopressin (anti-VP) and against vasopressin-associated glycopeptide (anti-VAG). All cases examined were negative for vasopressin gene expression using these antibodies. Alternatively, we examined 16 cases of breast ductal carcinoma in situ (DCIS) using the second of these antibodies (anti-VAG), and all of these cases were positive for vasopressin gene expression. Our results suggest that products of vasopressin gene expression are not markers of cellular proliferation in the breast, and might rather represent an early part of the carcinogenic process in this tissue.

Indexed as

BiopsyBreast NeoplasmsCarcinoma, DuctalFemaleFibrocystic Breast DiseaseGene Expression Regulation, NeoplasticHumansImmunohistochemistryRetrospective StudiesVasopressinsVasopressins

Identifiers

PMID14586071
OpenAlexW1999929065

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.