ReviewEndocrine pathology2003
Pheochromocytoma: rediscovery as a catecholamine-metabolizing tumor.
Review in Endocrine pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 67 citations in OpenAlex.
- Biochemical Diagnosis of Catecholamine-Producing Tumors of Childhood: Neuroblastoma, Pheochromocytoma and Paraganglioma.Frontiers in endocrinology · 2022Review
- Adrenal pheochromocytoma with involvement of aorta and left renal artery: salvaged with adrenalectomy and nephrectomy.BMJ case reports · 2021Article
- Do indices of baroreflex failure and peripheral noradrenergic deficiency predict the magnitude of orthostatic hypotension in Lewy body diseases?Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Article
- A high sensitivity LC-MS/MS method for measurement of 3-methoxytyramine in plasma and associations between 3-methoxytyramine, metanephrines, and dopamine.Journal of mass spectrometry and advances in the clinical lab · 2021Article
- Haemorrhagic retroperitoneal paraganglioma initially manifesting as acute abdomen: a rare case report and literature review.BMC surgery · 2020Review
- Utility ofAsia Oceania journal of nuclear medicine & biology · 2019Article
- Update on Adrenal Tumours in 2017 World Health Organization (WHO) of Endocrine Tumours.Endocrine pathology · 2017Review
- Current Diagnostic Status of Pheochromocytomaand Future Perspective: A Mini Review.Iranian journal of pathology · 2017Review
- Article
- Pheochromocytoma in Urologic Practice.European urology focus · 2016Article
- Development and validation of liquid chromatography-tandem mass spectrometry method for quantification of plasma metanephrines for differential diagnosis of adrenal incidentaloma.Annals of laboratory medicine · 2015Article
- Primary malignant hepatic paraganglioma mimicking liver tumor: A case report.Oncology letters · 2015Article
- The adrenal medulla and extra-adrenal paraganglia: then and now.Endocrine pathology · 2014Article
- Molecular and therapeutic advances in the diagnosis and management of malignant pheochromocytomas and paragangliomas.The oncologist · 2013Review
- Diagnostic tests and biomarkers for pheochromocytoma and extra-adrenal paraganglioma: from routine laboratory methods to disease stratification.Endocrine pathology · 2012Review
- Malignant abdominal paraganglioma presenting as a giant intra-peritoneal mass.International journal of surgery case reports · 2012Article
- Medical management of pheochromocytoma: Role of the endocrinologist.Indian journal of endocrinology and metabolism · 2011Article
- Recurrent urosepsis and cardiogenic shock in an elderly patient with pheochromocytoma.Case reports in endocrinology · 2011Article
- Pheochromocytoma and paraganglioma.Progress in brain research · 2010Article
- Molecular and cellular biology of pheochromocytomas and extra-adrenal paragangliomas.Endocrine pathology · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Catecholamine-producing tumors are rare neoplasms derived mainly from chromaffin cells of the adrenal medulla (pheochromocytomas) or, in about 10% of cases, from paraganglia (paragangliomas). Diagnosis of these tumors relies heavily on measurements of urinary or plasma catecholamines or catecholamine metabolites. The metabolites are usually thought to be produced after release of catecholamines into the bloodstream. This, however, ignores observations of over 40 yr ago that catecholamines are metabolized within pheochromocytoma tumor cells. Development of improved methods for measurement of catecholamine metabolites, in particular, plasma concentrations of free normetanephrine and metanephrine, has reestablished the importance of intratumoral catecholamine metabolism. In patients with pheochromocytoma, over 90% of the elevations in plasma free normetanephrine and metanephrine result from metabolism of catecholamines within pheochromocytoma tumor cells. This process occurs continuously and independently of variations in catecholamine release. As a consequence, measurements of plasma concentrations and urinary outputs of normetanephrine and metanephrine provide more reliable methods for diagnosis of pheochromocytoma than measurements of the parent amines. Rediscovery of the importance of intratumoral catecholamine metabolism is leading to a reevaluation of the procedures used to diagnose pheochromocytoma. This review provides an update on the diagnosis of pheochromocytoma, with emphasis on identifying and correcting relevant misconceptions about catecholamine metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.