Trial reportThorax2003
The role of neutrophil apoptosis in the resolution of acute lung injury in newborn infants.
Trial report in Thorax, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Intratracheal Clara cell secretory protein (CCSP) administration in preterm infants with or at risk of respiratory distress syndrome.The Cochrane database of systematic reviews · 2011Pooled it
- Elevated leukotriene B4 and 8-isoprostane in exhaled breath condensate from preterm-born infants.BMC pediatrics · 2023Article
- The Role of Insulin Receptor Substrate Proteins in Bronchopulmonary Dysplasia and Asthma: New Potential Perspectives.International journal of molecular sciences · 2022Review
- Neutrophils in community-acquired pneumonia: parallels in dysfunction at the extremes of age.Thorax · 2020Review
- The BPD trio? Interaction of dysregulated PDGF, VEGF, and TGF signaling in neonatal chronic lung disease.Molecular and cellular pediatrics · 2017Review
- Age-Appropriate Functions and Dysfunctions of the Neonatal Neutrophil.Frontiers in pediatrics · 2017Review
- Common respiratory conditions of the newborn.Breathe (Sheffield, England) · 2016Review
- Systemic inflammation on postnatal days 21 and 28 and indicators of brain dysfunction 2years later among children born before the 28th week of gestation.Early human development · 2016Article
- Postnatal Infections and Immunology Affecting Chronic Lung Disease of Prematurity.Clinics in perinatology · 2015Review
- Preclinical Models of Encephalopathy of Prematurity.Developmental neuroscience · 2015Review
- Intermittent or sustained systemic inflammation and the preterm brain.Pediatric research · 2014Review
- Macrophage phenotype is associated with disease severity in preterm infants with chronic lung disease.PloS one · 2014Article
- Cyclooxygenase-2 in newborn hyperoxic lung injury.Free radical biology & medicine · 2013Article
- Flice inhibitory protein is associated with the survival of neonatal neutrophils.Pediatric research · 2011Article
- Pathogenesis of indirect (secondary) acute lung injury.Expert review of respiratory medicine · 2011Review
- Resolution of cell-mediated airways diseases.Respiratory research · 2010Review
- Neonatal neutrophils with prolonged survival secrete mediators associated with chronic inflammation.Neonatology · 2010Article
- Siglec-9 and SHP-1 are differentially expressed in neonatal and adult neutrophils.Pediatric research · 2009Article
- Interleukin-10 versus dexamethasone: effects on polymorphonuclear leukocyte functions of the newborn.Pediatric research · 2009Article
- Inflammatory mediators in the immunobiology of bronchopulmonary dysplasia.Clinical reviews in allergy & immunology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe persistent airway neutrophilia observed in chronic lung disease of prematurity (CLD) may reflect inappropriate suppression of neutrophil apoptosis.
methods134 bronchoalveolar lavage (BAL) samples were obtained from 32 infants requiring mechanical ventilation for respiratory distress syndrome (RDS): 13 infants (median gestation 26 weeks, range 23 to 28) subsequently developed CLD (CLD group), and 19 infants (gestation 31 weeks, range 25 to 39) recovered fully (RDS group). A further 73 BAL samples were obtained from 20 infants (median age 2 days, range 1 to 402) receiving extracorporeal membrane oxygenation (ECMO) for severe respiratory failure.
resultsNeutrophil apoptosis was increased in the RDS group (mean (SEM) neutrophil apoptosis on day 7 BAL: RDS 17.0 (8.6)% v CLD 0.7 (0.2)% (p<0.05)). BAL fluid obtained from RDS but not CLD patients was proapoptotic to neutrophils (apoptosis ratio BAL fluid/saline control: day 1, RDS 9.8 (5.5) v CLD 1.2 (0.1) (p<0.05); day 2, RDS 4.32 (2.8) v CLD 0.5 (0.4) (p<0.05)). There were similar findings in the ECMO group: survivors had proapoptotic BAL fluid compared with non-survivors (apoptosis ratio day 1, survivors 7.9 (2.1) v non-survivors 2.1 (0.7) (p<0.05)).
conclusionsInappropriate suppression of neutrophil apoptosis may be associated with a poor outcome in newborn infants with respiratory failure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.