ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
R-cadherin is a Pax6-regulated, growth-promoting cue for pioneer axons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
29 citing papers in PubMed, 68 citations in OpenAlex.
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- SYCP2 Translocation-Mediated Dysregulation and Frameshift Variants Cause Human Male Infertility.American journal of human genetics · 2020Article
- Cdh4 Down-Regulation Impairs in Vivo Infiltration and Malignancy in Patients Derived Glioblastoma Cells.International journal of molecular sciences · 2019Article
- Mapping gene regulatory circuitry of Pax6 during neurogenesis.Cell discovery · 2016Article
- The role of cell adhesion molecules in visual circuit formation: from neurite outgrowth to maps and synaptic specificity.Developmental neurobiology · 2015Review
- Regulation of cadherin expression in nervous system development.Cell adhesion & migration · 2014Review
- Cortical plasticity within and across lifetimes: how can development inform us about phenotypic transformations?Frontiers in human neuroscience · 2013Review
- Irx3 and Pax6 establish differential competence for Shh-mediated induction of GABAergic and glutamatergic neurons of the thalamus.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Polygenic effects of common single-nucleotide polymorphisms on life span: when association meets causality.Rejuvenation research · 2012Article
- Slit-Robo signals regulate pioneer axon pathfinding of the tract of the postoptic commissure in the mammalian forebrain.Journal of neuroscience research · 2011Article
- Article
- Wiring the brain: the biology of neuronal guidance.Cold Spring Harbor perspectives in biology · 2010Review
- Cadherin-7 and cadherin-6B differentially regulate the growth, branching and guidance of cranial motor axons.Development (Cambridge, England) · 2010Article
- The predictability of evolution: glimpses into a post-Darwinian world.Die Naturwissenschaften · 2009Review
- Neuropilin 1-Sema signaling regulates crossing of cingulate pioneering axons during development of the corpus callosum.Cerebral cortex (New York, N.Y. : 1991) · 2009Article
- Potential for transcriptional upregulation of cochlin in glaucomatous trabecular meshwork: a combinatorial bioinformatic and biochemical analytical approach.Investigative ophthalmology & visual science · 2009Article
- Loss of retinal cadherin facilitates mammary tumor progression and metastasis.Cancer research · 2009Article
- Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidance.BMC developmental biology · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The transcription factor Pax6 has been implicated in two processes that may be related in brain development: establishment of regional cell adhesion properties and axon guidance. In Pax6 mutant mouse embryos, forebrain pioneer axons make pathfinding errors. These errors occur in a region of the ventral thalamus in which the expression of the cell adhesion molecule R-cadherin (Cdh4) is lost in Pax6 mutants. In vitro, an R-cadherin substrate promoted pioneer axon outgrowth. Furthermore, pioneer axon outgrowth was rescued in vivo by selective replacement of R-cadherin by electroporation into cultured Pax6 mutant embryos. Thus, these studies implicate Pax6 as an early brain patterning gene that establishes regional adhesive codes to guide pioneer axons.
Indexed as
Identifiers
14586016PMC2080860W1621316677What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.