ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Extinction requires new RNA and protein synthesis and the soma of the cell right pedal dorsal 1 in Lymnaea stagnalis.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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Who cites it
31 citing papers in PubMed.
- Neuroplastic Changes in the Superior Colliculus and Hippocampus in Self-rewarding Paradigm: Importance of Visual Cues.Molecular neurobiology · 2022Article
- What can we teach Lymnaea and what can Lymnaea teach us?Biological reviews of the Cambridge Philosophical Society · 2021Review
- Features of behavioral changes underlying conditioned taste aversion in the pond snail Lymnaea stagnalis.Invertebrate neuroscience : IN · 2020Article
- Function and mechanisms of memory destabilization and reconsolidation after retrieval.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2020Review
- Green tea and cocoa enhance cognition inCommunicative & integrative biology · 2018Article
- Training Lymnaea in the presence of a predator scent results in a long-lasting ability to form enhanced long-term memory.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2016Article
- Inverse Relationship between Basal Pacemaker Neuron Activity and Aversive Long-Term Memory Formation inFrontiers in cellular neuroscience · 2016Article
- Conditioned avoidance responses survive contingency degradation in the garden slug, Lehmannia valentiana.Learning & behavior · 2014Article
- In vitro extinction learning in Hermissenda: involvement of conditioned inhibition molecules.Frontiers in behavioral neuroscience · 2014Article
- Behavioral and neural bases of extinction learning in Hermissenda.Frontiers in behavioral neuroscience · 2014Article
- Critical period of memory enhancement during taste avoidance conditioning in Lymnaea stagnalis.PloS one · 2013Article
- Extinction of aversive memories associated with morphine withdrawal requires ERK-mediated epigenetic regulation of brain-derived neurotrophic factor transcription in the rat ventromedial prefrontal cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- The participation of NMDA receptors, PKC, and MAPK in the formation of memory following operant conditioning in Lymnaea.Molecular brain · 2010Article
- Spacing extinction trials alleviates renewal and spontaneous recovery.Learning & behavior · 2009Article
- Reconsolidation and the fate of consolidated memories.Neurotoxicity research · 2008Review
- Effects of a context shift and multiple context extinction on reactivity to alcohol cues.Experimental and clinical psychopharmacology · 2008Article
- Electrophysiological and behavioral evidence demonstrating that predator detection alters adaptive behaviors in the snail Lymnaea.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- A clash of stressors and LTM formation.Communicative & integrative biology · 2008Article
- Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear.Learning & memory (Cold Spring Harbor, N.Y.) · 2007Article
- Role of matrix metalloproteinases in the acquisition and reconsolidation of cocaine-induced conditioned place preference.Learning & memory (Cold Spring Harbor, N.Y.) · 2007Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lymnaea stagnalis were operantly conditioned to not perform aerial respiratory behavior. This learned response was subsequently extinguished. Here, we show that spaced extinction training is more effective than massed extinction training, in addition to the occurrence of spontaneous recovery. We also find evidence of a critical period within the first hour after extinction training in which new RNA and protein synthesis must occur for a memory of extinction training to be established. The memory for extinction training can also be extended using cooling and by preventing aerial respiration from occurring after extinction training. In addition, we demonstrate that memory formation of extinction training requires the soma of the cell right pedal dorsal 1, a cell that we have previously shown to be necessary for long-term memory consolidation and reconsolidation. This finding implies that the events that lead to the formation of extinction memory occur in the same cell that is responsible for long-term memory of operant conditioning. All of these data are consistent with the hypothesis that, during extinction, a new associative memory is being formed and that this new memory covers up, but does not abolish, the "old" memory.
Indexed as
Identifiers
14586013PMC6740901What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.