SynthesisThe Cochrane database of systematic reviews2003
Magnesium sulphate versus phenytoin for eclampsia.
Synthesis in The Cochrane database of systematic reviews, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus.The Cochrane database of systematic reviews · 2024Pooled it
- Quantifying the fall in mortality associated with interventions related to hypertensive diseases of pregnancy.BMC public health · 2011Pooled it
- Magnesium sulphate versus diazepam for eclampsia.The Cochrane database of systematic reviews · 2010Pooled it
- Magnesium sulphate and other anticonvulsants for women with pre-eclampsia.The Cochrane database of systematic reviews · 2010Pooled it
- Magnesium sulphate versus phenytoin for eclampsia.The Cochrane database of systematic reviews · 2010Pooled it
- Magnesium sulphate versus lytic cocktail for eclampsia.The Cochrane database of systematic reviews · 2010Pooled it
- Reducing stillbirths: interventions during labour.BMC pregnancy and childbirth · 2009Pooled it
- The Magpie Trial: a randomised trial comparing magnesium sulphate with placebo for pre-eclampsia. Outcome for children at 18 months.BJOG : an international journal of obstetrics and gynaecology · 2007Trial
- Diagnosis and Treatment of Eclampsia.Journal of cardiovascular development and disease · 2024Review
- Atypical Presentation of Antenatal Eclampsia.Cureus · 2022Article
- 'Magnesium'-the master cation-as a drug-possibilities and evidences.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2021Review
- Review
- Feasibility of task-sharing with community health workers for the identification, emergency management and referral of women with pre-eclampsia, in Mozambique.Reproductive health · 2021Article
- Use of Antihypertensive Drugs During Preeclampsia.Frontiers in cardiovascular medicine · 2018Article
- Magnesium sulfate treatment reverses seizure susceptibility and decreases neuroinflammation in a rat model of severe preeclampsia.PloS one · 2014Article
- Availability of treatment for eclampsia in public health institutions in Maharashtra, India.Journal of health, population, and nutrition · 2013Article
- [Preeclampsia and HELLP syndrome as an obstetric emergency].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2012Review
- The Impact of Magnesium Sulfate Therapy on Angiogenic Factors in Preeclampsia.Pregnancy hypertension · 2012Article
- A review of eclampsia in Qatar: A twenty-year study (from January 1991-December 2009).Qatar medical journal · 2012Review
- IL-6-induced pathophysiology during pre-eclampsia: potential therapeutic role for magnesium sulfate?International journal of interferon, cytokine and mediator research · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEclampsia, the occurrence of a convulsion (fit) in association with pre-eclampsia, remains a rare but serious complication of pregnancy. A number of different anticonvulsants are used to control eclamptic fits and to prevent further convulsions.
objectivesThe objective of this review was to assess the effects of magnesium sulphate compared with phenytoin when used for the care of women with eclampsia. Magnesium sulphate is compared with diazepam and with lytic cocktail in other Cochrane reviews. SEARCH STRATEGY: We searched the Cochrane Pregnancy and Childbirth trials register (28 November 2002) and the Cochrane Central Register of Controlled Trials (The Cochrane Library, Issue 4, 2002). SELECTION CRITERIA: Randomised trials comparing magnesium sulphate (intravenous or intramuscular administration) with phenytoin for women with a clinical diagnosis of eclampsia. DATA COLLECTION AND ANALYSIS: Both reviewers assessed trial quality and extracted data. MAIN
resultsSix trials involving 897 women are included. Most of the data are from trials of good quality. Magnesium sulphate is associated with a substantial reduction in the recurrence of convulsions, when compared to phenytoin (five trials, 895 women; relative risk (RR) 0.31, 95% confidence interval (CI) 0.20 to 0.47). The trend in maternal mortality favours magnesium sulphate, but this difference is not statistically significant (two trials, 797 women; RR 0.50, 95% CI 0.24 to 1.05). There are also reductions in the risk of pneumonia (RR 0.44, 95% CI 0.24 to 0.79), ventilation (RR 0.66, 95% CI 0.49 to 0.90) and admission to an intensive care unit (RR 0.67, 95% CI 0.50 to 0.89) associated with the use of magnesium sulphate. For the baby, magnesium sulphate was associated with fewer admissions to a special care baby unit (SCBU) (one trial, 518 babies; RR 0.73, 95% CI 0.58 to 0.91) and fewer babies who died or were in SCBU for more than seven days (one trial, 665 babies; RR 0.77, 95% CI 0.63 to 0.95). REVIEWER'S
conclusionsMagnesium sulphate appears to be substantially more effective than phenytoin for treatment of eclampsia.
Indexed as
Identifiers
14583911What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.