SynthesisThe Cochrane database of systematic reviews2003
Magnesium sulphate versus diazepam for eclampsia.
Synthesis in The Cochrane database of systematic reviews, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 6 syntheses or guidelines pooled it, 132 citations in OpenAlex.
- Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus.The Cochrane database of systematic reviews · 2024Pooled it
- Quantifying the fall in mortality associated with interventions related to hypertensive diseases of pregnancy.BMC public health · 2011Pooled it
- Magnesium sulphate and other anticonvulsants for women with pre-eclampsia.The Cochrane database of systematic reviews · 2010Pooled it
- Magnesium sulphate versus phenytoin for eclampsia.The Cochrane database of systematic reviews · 2010Pooled it
- Magnesium sulphate versus lytic cocktail for eclampsia.The Cochrane database of systematic reviews · 2010Pooled it
- Reducing stillbirths: interventions during labour.BMC pregnancy and childbirth · 2009Pooled it
- The Magpie Trial: a randomised trial comparing magnesium sulphate with placebo for pre-eclampsia. Outcome for children at 18 months.BJOG : an international journal of obstetrics and gynaecology · 2007Trial
- Atypical Presentation of Antenatal Eclampsia.Cureus · 2022Article
- 'Magnesium'-the master cation-as a drug-possibilities and evidences.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2021Review
- The Fabrication of a Gellan Gum-Based Hydrogel Loaded With Magnesium Ions for the Synergistic Promotion of Skin Wound Healing.Frontiers in bioengineering and biotechnology · 2021Article
- Use of Antihypertensive Drugs During Preeclampsia.Frontiers in cardiovascular medicine · 2018Article
- The comparison of anti-seizure and tocolytic effects of phenytoin and magnesium sulphate in the treatment of eclampsia and preeclampsia: A randomised clinical trial.Iranian journal of neurology · 2017Article
- Better than nothing? maternal, newborn, and child health services and perinatal mortality, Lubumbashi, democratic republic of the Congo: a cohort study.BMC pregnancy and childbirth · 2016Article
- Causes of maternal mortality in Ethiopia: a significant decline in abortion related death.Ethiopian journal of health sciences · 2014Article
- Magnesium sulfate treatment reverses seizure susceptibility and decreases neuroinflammation in a rat model of severe preeclampsia.PloS one · 2014Article
- Prevention and management of severe pre-eclampsia/eclampsia in Afghanistan.BMC pregnancy and childbirth · 2013Article
- Availability of treatment for eclampsia in public health institutions in Maharashtra, India.Journal of health, population, and nutrition · 2013Article
- [Epidemiological profile and management of eclampsia in Senegal: about 62 cases].The Pan African medical journal · 2013Article
- A review of eclampsia in Qatar: A twenty-year study (from January 1991-December 2009).Qatar medical journal · 2012Review
- The Impact of Magnesium Sulfate Therapy on Angiogenic Factors in Preeclampsia.Pregnancy hypertension · 2012Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEclampsia, the occurrence of a convulsion in association with pre-eclampsia, remains a rare but serious complication of pregnancy. A number of different anticonvulsants are used to control eclamptic fits and to prevent further fits.
objectivesThe objective of this review was to assess the effects of magnesium sulphate compared with diazepam when used for the care of women with eclampsia. Magnesium sulphate is compared with phenytoin and with lytic cocktail in other Cochrane reviews. SEARCH STRATEGY: We searched the Cochrane Pregnancy and Childbirth trials register (28 November 2002) and the Cochrane Central Register of Controlled Trials (The Cochrane Library, Issue 4, 2002). SELECTION CRITERIA: Randomised trials comparing magnesium sulphate (intravenous or intramuscular administration) with diazepam for women with a clinical diagnosis of eclampsia. DATA COLLECTION AND ANALYSIS: Both reviewers assessed and extracted data. MAIN
resultsSeven trials involving 1441 women are included. Most of the data are from trials of good quality. Magnesium sulphate is associated with a reduction in maternal death when compared to diazepam (six trials 1336 women; relative risk (RR) 0.59, 95% confidence interval (CI) 0.37 to 0.94). There is also a substantial reduction in the risk recurrence of further fits (seven trials 1441 women; RR 0.44, 95% CI 0.34 to 0.57). There were few differences in any other measures of outcome, except for fewer Apgar scores less than seven at five minutes (two trials 597 babies; RR 0.72, 95% CI 0.55 to 0.94) and fewer babies with a length of stay in special care baby unit more than seven days (three trials 631 babies; RR 0.66, 95% CI 0.46 to 0.95) associated with magnesium sulphate. REVIEWER'S
conclusionsMagnesium sulphate appears to be substantially more effective than diazepam for treatment of eclampsia.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.