ArticleThe pharmacogenomics journal2003
Haplotypes of the cholesteryl ester transfer protein gene predict lipid-modifying response to statin therapy.
Article in The pharmacogenomics journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- Genetic Determinants of Response to Statins in Cardiovascular Diseases.Current cardiology reviews · 2024Review
- Association ofInternational journal of molecular sciences · 2023Article
- The Effect of Haplotypes in theGenes · 2020Article
- Laboratory Medicine in the Clinical Decision Support for Treatment of Hypercholesterolemia: Pharmacogenetics of Statins.Clinics in laboratory medicine · 2016Review
- Pharmacogenomics of high-density lipoprotein-cholesterol-raising therapies.Expert review of cardiovascular therapy · 2013Review
- Circulating plasma cholesteryl ester transfer protein activity and blood pressure tracking in the community.Journal of hypertension · 2011Article
- Single nucleotide polymorphisms in genes that are associated with a modified response to statin therapy: the Rotterdam Study.The pharmacogenomics journal · 2011Article
- Polymorphisms in maternal and fetal genes encoding for proteins involved in extracellular matrix metabolism alter the risk for small-for-gestational-age.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2011Article
- A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).American journal of obstetrics and gynecology · 2010Article
- Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.American journal of obstetrics and gynecology · 2010Article
- Modeling genetic imprinting effects of DNA sequences with multilocus polymorphism data.Algorithms for molecular biology : AMB · 2009Article
- Pharmacogenetics of cardiovascular drug therapy.Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases · 2009Article
- Cholesteryl ester transfer protein (CETP) genetic variation and early onset of non-fatal myocardial infarction.Annals of human genetics · 2008Article
- Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin.Circulation · 2008Article
- Pharmacogenetics: potential role in the treatment of diabetes and obesity.Expert opinion on pharmacotherapy · 2008Review
- A general quantitative genetic model for haplotyping a complex trait in humans.Current genomics · 2007Article
- Cholesteryl ester transfer protein gene haplotypes, plasma high-density lipoprotein levels and the risk of coronary heart disease.Human genetics · 2007Article
- An efficient method for multi-locus molecular haplotyping.Nucleic acids research · 2007Article
- Direct molecular haplotyping by melting curve analysis of hybridization probes: beta 2-adrenergic receptor haplotypes as an example.Nucleic acids research · 2005Article
- Pharmacogenetics of response to statins: where do we stand?Current atherosclerosis reports · 2005Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cholesteryl ester transfer protein (CETP) plays a central role in high-density lipoprotein (HDL) metabolism. Single nucleotide polymorphisms (SNPs) and haplotypes in the CETP gene were determined in 98 patients with untreated dyslipidemias and analyzed for associations with plasma CETP and plasma lipids before and during statin treatment. Individual CETP SNPs and haplotypes were both significantly associated with CETP enzyme mass and activity. However, only certain CETP haplotypes, but not individual SNPs, significantly predicted the magnitude of change in HDL cholesterol (HDL-C) and triglycerides. After adjusting for covariates and multiple testing, the TTCAAA haplotype showed a gene-dose effect in predicting the HDL-C increase (P=0.03), while the TTCAAAGGG and AAAGGG haplotypes predicted a decrease in triglycerides (P=0.04 both). This is the first study to demonstrate that SNP haplotypes derived from allelic SNP combinations in the CETP gene were more informative than single SNPs in predicting the response to lipid-modifying therapy with statins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.