ArticleProceedings of the National Academy of Sciences of the United States of America2003
Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- Mechanisms promoting escape from mitotic stress-induced tumor cell death.Cancer research · 2014Article
- Strain-specific variation in murine natural killer gene complex contributes to differences in immunosurveillance for urethane-induced lung cancer.Cancer research · 2012Article
- Inhibition of P-glycoprotein leads to improved oral bioavailability of compound K, an anticancer metabolite of red ginseng extract produced by gut microflora.Drug metabolism and disposition: the biological fate of chemicals · 2012Article
- Most lung and colon cancer susceptibility genes are pair-wise linked in mice, humans and rats.PloS one · 2011Article
- Epistatic interactions govern chemically-induced lung tumor susceptibility and Kras mutation site in murine C57BL/6J-ChrA/J chromosome substitution strains.International journal of cancer · 2010Article
- IC97 is a novel intermediate chain of I1 dynein that interacts with tubulin and regulates interdoublet sliding.Molecular biology of the cell · 2009Article
- Cis-acting genomic elements of the Pas1 locus control Kras mutability in lung tumors.Oncogene · 2008Article
- Article
- Identification of the functional role of peroxiredoxin 6 in the progression of breast cancer.Breast cancer research : BCR · 2007Article
- A functional switch from lung cancer resistance to susceptibility at the Pas1 locus in Kras2LA2 mice.Nature genetics · 2006Article
- Genetics of susceptibility to leishmaniasis in mice: four novel loci and functional heterogeneity of gene effects.Genes and immunity · 2006Article
- Fine mapping of a major locus on chromosome 10 for exploratory and fear-like behavior in mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2005Article
- Tobacco smoke-induced lung tumorigenesis in mutant A/J mice with alterations in K-ras, p53, or Ink4a/Arf.Oncogene · 2005Article
- Article
- KIAA0008 gene is associated with invasive phenotype of human hepatocellular carcinoma--a functional analysis.Journal of cancer research and clinical oncology · 2004Article
- Article
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8 authors at 1 institution in 1 country.
Funding
Abstract
Pulmonary adenoma susceptibility 1 (Pas1), located on chromosome 6, is the major locus affecting inherited predisposition to lung tumor development in mice. We have fine mapped the Pas1 locus to a region of approximately 0.5 megabases by using congenic strains of mice, constructed by placing the Pas1 region of chromosome 6 from A/J mice onto the genetic background of C57BL/6J mice. Systematic characterization of Pas1 candidates establishes the Las1 (lung adenoma susceptibility 1) and Kras2 (Kirsten rat sarcoma oncogene 2) genes as primary candidates for the Pas1 locus. Clearly, Kras2 affects lung tumor progression only, and Las1 is likely to affect lung tumor multiplicity.
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