ArticleThe Journal of general physiology2003
Allosteric activation of sodium-calcium exchange activity by calcium: persistence at low calcium concentrations.
Article in The Journal of general physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- Modulation of the cardiac NaCell calcium · 2020Review
- Selective inhibition of mitochondrial sodium-calcium exchanger protects striatal neurons from α-synuclein plus rotenone induced toxicity.Cell death & disease · 2019Article
- Glutamate as a potential "survival factor" in an in vitro model of neuronal hypoxia/reoxygenation injury: leading role of the NaCell death & disease · 2018Article
- Na+/Ca2+ exchange and Na+/K+-ATPase in the heart.The Journal of physiology · 2015Review
- Na⁺ transport in the normal and failing heart - remember the balance.Journal of molecular and cellular cardiology · 2013Review
- Cardiac Na+-Ca2+ exchanger: dynamics of Ca2+-dependent activation and deactivation in intact myocytes.The Journal of physiology · 2013Article
- Interpreting genetic effects through models of cardiac electromechanics.American journal of physiology. Heart and circulatory physiology · 2012Review
- Data-based theoretical identification of subcellular calcium compartments and estimation of calcium dynamics in cardiac myocytes.The Journal of physiology · 2012Article
- Ca2+-dependent structural rearrangements within Na+-Ca2+ exchanger dimers.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Dual inhibition of sodium-mediated proton and calcium efflux triggers non-apoptotic cell death in malignant gliomas.Brain research · 2010Article
- Modeling mitochondrial bioenergetics with integrated volume dynamics.PLoS computational biology · 2010Article
- Na+ transport in cardiac myocytes; Implications for excitation-contraction coupling.IUBMB life · 2009Article
- PKC-Independent Stimulation of Cardiac Na/Ca Exchanger by Staurosporine.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2008Article
- Sodium-dependent inactivation of sodium/calcium exchange in transfected Chinese hamster ovary cells.American journal of physiology. Cell physiology · 2008Article
- Steady-state coupling of plasma membrane calcium entry to extrusion revealed by novel L-type calcium channel block.Cell calcium · 2008Article
- A kinetic model for calcium dynamics in RAW 264.7 cells: 2. Knockdown response and long-term response.Biophysical journal · 2007Article
- Sodium-calcium exchange does not require allosteric calcium activation at high cytosolic sodium concentrations.The Journal of physiology · 2006Article
- Synergistic interactions between Ca2+ entries through L-type Ca2+ channels and Na+-Ca2+ exchanger in normal and failing rat heart.The Journal of physiology · 2005Article
- Computational model of the cAMP-mediated sensory response and calcium-dependent adaptation in vertebrate olfactory receptor neurons.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Allosteric activation of sodium-calcium exchange by picomolar concentrations of cadmium.The Journal of physiology · 2005Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The activity of the cardiac Na+/Ca2+ exchanger is stimulated allosterically by Ca2+, but estimates of the half-maximal activating concentration have varied over a wide range. In Chinese hamster ovary cells expressing the cardiac Na+/Ca2+ exchanger, the time course of exchange-mediated Ca2+ influx showed a pronounced lag period followed by an acceleration of Ca2+ uptake. Lag periods were absent in cells expressing an exchanger mutant that was not dependent on regulatory Ca2+ activation. We assumed that the rate of Ca2+ uptake during the acceleration phase reflected the degree of allosteric activation of the exchanger and determined the value of cytosolic Ca2+ ([Ca2+]i) at which the rate of Ca2+ influx was half-maximal (Kh). After correcting for the effects of mitochondrial Ca2+ uptake and fura-2 buffering, Kh values of approximately 300 nM were obtained. After an increase in [Ca2+]i, the activated state of the exchanger persisted following a subsequent reduction in [Ca2+]i to values <100 nM. Thus, within 30 s after termination of a transient increase in [Ca2+]i, exchange-mediated Ca2+ entry began without a lag period and displayed a linear rate of Ca2+ uptake in most cells; a sigmoidal time course of Ca2+ uptake returned 60-90 s after the transient increase in [Ca2+]i was terminated. Relaxation of the activated state was accelerated by the activity of the endoplasmic reticulum Ca2+ pump, suggesting that local Ca2+ gradients contribute to maintaining exchanger activation after the return of global [Ca2+]i to low values.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.