ArticleBiophysical journal2003
Modeling the role of myosin 1c in neuronal growth cone turning.
Article in Biophysical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Myosin-I synergizes with Arp2/3 complex to enhance the pushing forces of branched actin networks.Science advances · 2024Article
- Myosin-I Synergizes with Arp2/3 Complex to Enhance Pushing Forces of Branched Actin Networks.bioRxiv : the preprint server for biology · 2024Article
- Membrane-bound myosin IC drives the chiral rotation of the gliding actin filament around its longitudinal axis.Scientific reports · 2023Article
- Review
- Mathematical models of neuronal growth.Biomechanics and modeling in mechanobiology · 2022Review
- A Statistically-Oriented Asymmetric Localization (SOAL) Model for Neuronal Outgrowth Patterning byGenetics · 2018Article
- RNA localization is a key determinant of neurite-enriched proteome.Nature communications · 2017Article
- Nuclear myosin I regulates cell membrane tension.Scientific reports · 2016Article
- Myosin-I molecular motors at a glance.Journal of cell science · 2016Review
- High-throughput sequencing of the synaptome in major depressive disorder.Molecular psychiatry · 2016Article
- Mechanochemical regulation of growth cone motility.Frontiers in cellular neuroscience · 2015Review
- Synergistic effects of 3D ECM and chemogradients on neurite outgrowth and guidance: a simple modeling and microfluidic framework.PloS one · 2014Article
- Functional roles for myosin 1c in cellular signaling pathways.Cellular signalling · 2013Review
- Membrane tension, myosin force, and actin turnover maintain actin treadmill in the nerve growth cone.Biophysical journal · 2012Article
- Cytoskeletal coherence requires myosin-IIA contractility.Journal of cell science · 2010Article
- Adenomatous polyposis coli is differentially distributed in growth cones and modulates their steering.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- The forces behind cell movement.International journal of biological sciences · 2007Review
- Growth cone pathfinding: a competition between deterministic and stochastic events.BMC neuroscience · 2004Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We addressed the mechanical basis for how embryonic chick dorsal root ganglion growth cones turn on a uniform substrate of laminin-1. Turning is significantly correlated with lamellipodial area but not with filopodial length. We assessed the lamellipodial contribution to turning by asymmetric micro-CALI of myosin isoforms that causes localized lamellipodial expansion (myosin 1c) or filopodial retraction (myosin V). Episodes of asymmetric micro-CALI of myosin 1c (or myosin 1c and V together) caused significant turning of the growth cone. In contrast, repeated micro-CALI of myosin V or irradiation without added antibody did not turn growth cones. These findings argue that lamellipodia and not filopodia are necessary for growth cone turning. To model the role of myosin 1c on growth cone turning, we fitted the measured trajectories from asymmetric micro-CALI of myosin 1c-treated and untreated growth cones to the persistent random walk model. The first parameter in this equation, root-mean-square speed, is indistinguishable between the two data sets whereas the second parameter, the persistence of motion, is significantly increased (2.5-fold) as a result of asymmetric inactivation of myosin 1c by micro-CALI. This analysis demonstrates that growth cone turning results from an increase in the persistence of directional motion rather than a change in speed. Taken together, our results suggest that myosin 1c is a molecular correlate for directional persistence underlying growth cone motility.
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Registered trials
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