ReviewPaediatric drugs2003
Neonatal sepsis: epidemiology and management.
Review in Paediatric drugs, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 73 citations in OpenAlex.
- Evolution of Antimicrobial Resistance in Neonatal Sepsis: A Narrative Review.Antibiotics (Basel, Switzerland) · 2026Review
- Clinical impact of an antibiotic stewardship program in a neonatal intensive care unit at a tertiary care hospital: a prospective quasi-experimental clinical study.Journal of pharmaceutical health care and sciences · 2025Article
- Nanomaterial Modified Screen Printed Electrode Based Electrochemical Genosensor for Efficient Detection of Neonatal Sepsis.Indian journal of microbiology · 2025Article
- Late-onset neonatal sepsis: genetic differences by sex and involvement of the NOTCH pathway.Pediatric research · 2023Article
- Salivary and Serum Interleukin-10, C-Reactive Protein, Mean Platelet Volume, and CRP/MPV Ratio in the Diagnosis of Late-Onset Neonatal Sepsis in Full-Term Neonates.Journal of immunology research · 2021Observational
- Article
- Using newborn screening analytes to identify cases of neonatal sepsis.Scientific reports · 2017Article
- Evaluation of Vancomycin Use in Late-Onset Neonatal Sepsis Using the Area Under the Concentration-Time Curve to the Minimum Inhibitory Concentration ≥400 Target.Therapeutic drug monitoring · 2015Article
- Biological functions of thyroid hormone in placenta.International journal of molecular sciences · 2015Review
- Soluble ST2, a modulator of the inflammatory response, in preterm and term labor.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2014Article
- Endoglin in amniotic fluid as a risk factor for the subsequent development of bronchopulmonary dysplasia.American journal of reproductive immunology (New York, N.Y. : 1989) · 2013Article
- Bench-to-bedside review: Neonatal sepsis-redox processes in pathogenesis.Critical care (London, England) · 2012Review
- Choice and duration of antimicrobial therapy for neonatal sepsis and meningitis.International journal of pediatrics · 2011Article
- Bench-to-bedside review: sepsis - from the redox point of view.Critical care (London, England) · 2011Review
- The changing spectrum of neonatal infectious disease.Journal of perinatology : official journal of the California Perinatal Association · 2010Review
- Identification of diagnostic biomarkers for infection in premature neonates.Molecular & cellular proteomics : MCP · 2008Article
- Low mannose-binding lectin (MBL) levels in neonates with pneumonia and sepsis.Clinical and experimental immunology · 2007Article
- Antifungal agents in neonates: issues and recommendations.Paediatric drugs · 2007Review
- High prevalence of mannose-binding lectin (MBL) deficiency in premature neonates.Clinical and experimental immunology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neonatal sepsis is uncommon (2-4 per 1000 live births in developed countries), but the rate increases dramatically in premature newborns and those born to mothers with infections or prolonged rupture of the fetal membranes. While infections caused by organisms contracted from the mother at birth have decreased in the past two decades, there has been an increase in nosocomial infections. Today, most infants with sepsis have been hospitalized in neonatal intensive care units for weeks or months because of extreme prematurity, or because of a congenital malformation or surgical condition. Antimicrobial therapy is usually begun prior to the isolation of a pathogen and is based upon knowledge of the likely microbes in the particular clinical situation. The number of antimicrobial agents that can be safely used in neonates is relatively small, and dose administration usually needs to be adjusted based upon birthweight and post-gestational age. The decision whether to treat with antimicrobials should be made with consideration of the history, physical examination, and laboratory data. One should also consider the effects of the use of antimicrobials on the flora of the care unit. Bacterial resistance in the resident flora of the unit has become a major problem where there has been indiscriminate use of broad-spectrum agents.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.