ArticleChromosoma2003
The ThioredoxinT and deadhead gene pair encode testis- and ovary-specific thioredoxins in Drosophila melanogaster.
Article in Chromosoma, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 49 citations in OpenAlex.
- Tissue-specific transcriptomic analysis of accelerated reproductive development of immature Queensland fruit fly induced by raspberry ketone ingestion.BMC genomics · 2026Article
- TrxT and dhd are dispensable for Drosophila brain development but essential for l(3)mbt brain tumour growth.EMBO reports · 2024Article
- Molecular identification of two thioredoxin genes and their function in antioxidant defense inFrontiers in physiology · 2024Article
- The evolutionarily conserved PhLP3 is essential for sperm development in Drosophila melanogaster.PloS one · 2024Article
- Three classes of epigenomic regulators converge to hyperactivate the essential maternal gene deadhead within a heterochromatin mini-domain.PLoS genetics · 2022Article
- Sperm Redox System Equilibrium: Implications for Fertilization and Male Fertility.Advances in experimental medicine and biology · 2022Article
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- Dynamic redox balance directs the oocyte-to-embryo transition via developmentally controlled reactive cysteine changes.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- RNA Interference-Mediated Knockdown of Male Fertility Genes in the Queensland Fruit FlyInsects · 2018Article
- Molecular Identification of Two Thioredoxin Genes FromFrontiers in physiology · 2018Article
- AnOpen biology · 2017Article
- Unlocking sperm chromatin at fertilization requires a dedicated egg thioredoxin in Drosophila.Nature communications · 2016Article
- An unregulated regulator: Vasa expression in the development of somatic cells and in tumorigenesis.Developmental biology · 2016Review
- Sequence analysis, expression profiles and function of thioredoxin 2 and thioredoxin reductase 1 in resistance to nucleopolyhedrovirus in Helicoverpa armigera.Scientific reports · 2015Article
- Involvement of redox state in the aging of Drosophila melanogaster.Antioxidants & redox signaling · 2013Review
- Targeting of Painting of fourth to roX1 and roX2 proximal sites suggests evolutionary links between dosage compensation and the regulation of the fourth chromosome in Drosophila melanogaster.G3 (Bethesda, Md.) · 2013Article
- Autosomal mutations affecting Y chromosome loops in Drosophila melanogaster.BMC genetics · 2008Article
- Organization and regulation of sex-specific thioredoxin encoding genes in the genus Drosophila.Development genes and evolution · 2007Article
- Painting of fourth and chromosome-wide regulation of the 4th chromosome in Drosophila melanogaster.The EMBO journal · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
So far, two thioredoxin proteins, DHD and Trx-2, have been biochemically characterized in Drosophila melanogaster. Here, with the cloning and characterization of TrxT we describe an additional thioredoxin with testis-specific expression. TrxT and dhd are arranged as a gene pair, transcribed in opposite directions and sharing a 471 bp regulatory region. We show that this regulatory region is sufficient for correct expression of the two genes. This gene pair makes a good model for unraveling how closely spaced promoters are differentially regulated by a short common control region. Both TrxT and DHD proteins are localized within the nuclei in testes and ovaries, respectively. Use of a transgenic construct expressing TrxT fused to Enhanced Yellow Fluorescent Protein reveals a clear association of TrxT with the Y chromosome lampbrush loops ks-1 and kl-5 in primary spermatocytes. The association is lost in the absence of the Y chromosome. Our results suggest that nuclear thioredoxins may have regulatory functions in the germline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.