ArticleChromosoma2003
Rearrangements of ribosomal DNA clusters in late generation telomerase-deficient Arabidopsis.
Article in Chromosoma, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed.
- Plant Cytogenetics in the Micronuclei Investigation-The Past, Current Status, and Perspectives.International journal of molecular sciences · 2022Review
- Cytogenetic events in the endosperm of amphiploid Avena magna × A. longiglumis.Journal of plant research · 2021Article
- Architecture and evolution of subtelomeres in the unicellular green alga Chlamydomonas reinhardtii.Nucleic acids research · 2021Article
- DetectingInternational journal of molecular sciences · 2019Article
- Dissecting the chromosomal composition of mutagen-induced micronuclei in Brachypodium distachyon using multicolour FISH.Annals of botany · 2018Article
- Brachypodium distachyon - A Useful Model in the Qualification of Mutagen-Induced Micronuclei Using Multicolor FISH.PloS one · 2017Article
- Dual Role of a SAS10/C1D Family Protein in Ribosomal RNA Gene Expression and Processing Is Essential for Reproduction in Arabidopsis thaliana.PLoS genetics · 2016Article
- A telomerase-independent component of telomere loss in chromatin assembly factor 1 mutants of Arabidopsis thaliana.Chromosoma · 2013Article
- Chromosome breakages associated with 45S ribosomal DNA sequences in spotted snakehead fish Channa punctatus.Molecular biology reports · 2013Article
- NBS1 plays a synergistic role with telomerase in the maintenance of telomeres in Arabidopsis thaliana.BMC plant biology · 2012Article
- Plant 45S rDNA clusters are fragile sites and their instability is associated with epigenetic alterations.PloS one · 2012Article
- End joining at Caenorhabditis elegans telomeres.Genetics · 2008Article
- Article
- Role of alternative telomere lengthening unmasked in telomerase knock-out mutant plants.Plant molecular biology · 2008Article
- Genealogical relationships of southern Ontario polyploid unisexual salamanders (genus Ambystoma) inferred from intergenomic exchanges and major rDNA cytotypes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Article
- Suppression of RICE TELOMERE BINDING PROTEIN 1 results in severe and gradual developmental defects accompanied by genome instability in rice.The Plant cell · 2007Article
- Comparative genetic mapping in Boechera stricta, a close relative of Arabidopsis.Plant physiology · 2007Article
- Homeologous recombination plays a major role in chromosome rearrangements that occur during meiosis of Brassica napus haploids.Genetics · 2007Article
- Multicolour FISH in an analysis of chromosome aberrations induced by N-nitroso-N-methylurea and maleic hydrazide in barley cells.Journal of applied genetics · 2007Article
- Mechanisms of chromosome number reduction in Arabidopsis thaliana and related Brassicaceae species.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ends of eukaryotic chromosomes are capped with special nucleoprotein structures called telomeres. Telomere shortening due to telomerase inactivation may result in fusion of homologous or heterologous chromosomes, leading to their successive breakage during anaphase movement, followed by fusion of broken ends in the next cell cycle, i.e. the breakage-fusion-bridge (BFB) cycle. Using fluorescence in situ hybridization (FISH) with 25S rDNA and specific bacterial artificial chromosome (BAC) probes we demonstrate participation of chromosomes 2 and 4 of Arabidopsis thaliana AtTERT null plants in the formation of anaphase bridges. Both homologous and non-homologous chromosomes formed transient anaphase bridges whose breakage and unequal separation led to genome rearrangement, including non-reciprocal translocations and aneuploidy. The 45S rDNA regions located at the ends of chromosomes 2 and 4 were observed in chromosome bridges at a frequency approximately ten times higher than expected in the case of random fusion events. This outcome could result from a functional association of rDNA repeats at nucleoli. We also describe increased variation in the number of nucleoli in some interphase cells with supernumerary rDNA FISH signals. These data indicate that dysfunctional telomeres in Arabidopsis lead to massive genome instability, which is induced by multiple rounds of the BFB mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.