ArticlePflugers Archiv : European journal of physiology2004
Identification of a non-selective cation channel current in myometrial cells isolated from pregnant rats.
Article in Pflugers Archiv : European journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 34 citations in OpenAlex.
- Study of Magnesium Formulations on Intestinal Cells to Influence Myometrium Cell Relaxation.Nutrients · 2020Article
- Sodium channels and transporters in the myometrium.Current opinion in physiology · 2020Article
- Na+-Leak Channel, Non-Selective (NALCN) Regulates Myometrial Excitability and Facilitates Successful Parturition.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2018Article
- Sodium leak channel, non-selective contributes to the leak current in human myometrial smooth muscle cells from pregnant women.Molecular human reproduction · 2015Article
- NALCN: a regulator of pacemaker activity.Molecular neurobiology · 2012Review
- Article
- From cardiac cation channels to the molecular dissection of the transient receptor potential channel TRPM4.Pflugers Archiv : European journal of physiology · 2006Review
- Decavanadate modulates gating of TRPM4 cation channels.The Journal of physiology · 2004Article
- Non-selective cationic channels of smooth muscle and the mammalian homologues of Drosophila TRP.The Journal of physiology · 2004Review
- Two types of non-selective cation channel opened by muscarinic stimulation with carbachol in bovine ciliary muscle cells.The Journal of physiology · 2004Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-selective cation channel (NSCC) currents were identified in myometrial smooth muscle cells isolated from pregnant rats (day 18-20) using the whole-cell patch clamp method. NSCC currents had a linear current/voltage relationship and were time independent. Reduction of extracellular Na(+) substantially decreased the amplitude of NSCC currents, indicating that the NSCC is permeable to Na(+). NSCC currents were blocked by La(3+) and Gd(3+) with K(d) values of 2.2 and 1.0 micro M, respectively. The relative permeability of various monovalent cations for NSCC was estimated by measurement of the reversal potential. The relative permeability for K(+):Cs(+):Na(+):Li(+) was 1.3:1:0.9:0.8. NSCC also had a small, but detectable, permeability for Ca(2+). Extracellular Mg(2+) inhibited myometrial NSCC currents concentration dependently with a K(d) of 0.28 mM. The observed Mg(2+) block may reasonably explain the inhibitory effect of magnesium on uterine contractions in the treatment of pre-term labor. Our results suggest that the NSCC plays a role in the regulation of myometrial contractility.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.