ArticleThe Journal of physiology2004
Modulation of afterpotentials and firing pattern in guinea pig CA3 neurones by group I metabotropic glutamate receptors.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Modulation of intrinsic excitability as a function of learning within the fear conditioning circuit.Neurobiology of learning and memory · 2020Review
- Synergy of Glutamatergic and Cholinergic Modulation Induces Plateau Potentials in Hippocampal OLM Interneurons.Frontiers in cellular neuroscience · 2019Article
- Modulation of the input-output function by GABAA receptor-mediated currents in rat oculomotor nucleus motoneurons.The Journal of physiology · 2014Article
- Interaction of DHPG-LTD and synaptic-LTD at senescent CA3-CA1 hippocampal synapses.Hippocampus · 2014Article
- Dendritic generation of mGluR-mediated slow afterdepolarization in layer 5 neurons of prefrontal cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Persistent receptor activity underlies group I mGluR-mediated cellular plasticity in CA3 neuron.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Glutamate modulates the firing rate in oculomotor nucleus motoneurons as a function of the recruitment threshold current.The Journal of physiology · 2012Article
- Synergistic actions of metabotropic acetylcholine and glutamate receptors on the excitability of hippocampal CA1 pyramidal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Altered neocortical rhythmic activity states in Fmr1 KO mice are due to enhanced mGluR5 signaling and involve changes in excitatory circuitry.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- mGluRs modulate strength and timing of excitatory transmission in hippocampal area CA3.Molecular neurobiology · 2011Review
- Cyclic ADP ribose-dependent Ca2+ release by group I metabotropic glutamate receptors in acutely dissociated rat hippocampal neurons.PloS one · 2011Article
- Article
- Muscarinic receptor activation modulates the excitability of hilar mossy cells through the induction of an afterdepolarization.Brain research · 2010Article
- Activation of mGluR5 induces spike afterdepolarization and enhanced excitability in medium spiny neurons of the nucleus accumbens by modulating persistent Na+ currents.The Journal of physiology · 2009Article
- Mechanisms underlying low [Ca(2+)](o)-induced increased excitability of hippocampal neurons.Neuroscience bulletin · 2008Article
- Distinct classes of pyramidal cells exhibit mutually exclusive firing patterns in hippocampal area CA3b.Hippocampus · 2008Article
- Receptor-specific inhibition of GABAB-activated K+ currents by muscarinic and metabotropic glutamate receptors in immature rat hippocampus.The Journal of physiology · 2007Article
- Physiologic regulation of a tetrodotoxin-sensitive sodium influx that mediates a slow afterdepolarization potential in gonadotropin-releasing hormone neurons: possible implications for the central regulation of fertility.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Distinct subunits in heteromeric kainate receptors mediate ionotropic and metabotropic function at hippocampal mossy fiber synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Abrupt maturation of a spike-synchronizing mechanism in neocortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Activation of group I metabotropic glutamate receptors (mGluRs) alters the firing patterns of individual CA3 pyramidal cells in guinea pig hippocampal slices. Following addition of the selective group I agonist (S)-3,5-dihydroxyphenylglycine (DHPG) to the bathing solution, pyramidal cells initially firing regular, single action potentials switched to firing in brief bursts. This change in firing pattern resulted from modulation by mGluRs of three afterpotentials. The medium and slow afterhyperpolarizations (m and sAHPs) were blocked by mGluR activation. In addition, a voltage-dependent after depolarization (ADP) was induced. Recordings from mutant mice lacking phospholipase C(beta1) (PLC(beta1)) showed that mGluR block of the mAHP, as well as induction of the ADP, depended on the phosphoinositide hydrolysis pathway. Block of the sAHP, however, was partly spared in the absence of PLC(beta1). Optical recordings of post spike intracellular Ca(2+) rises showed that mGluR block of the AHP was not mediated by alterations of action potential-associated Ca(2+) increases (Ca(2+) transients). The mGluR induction of an ADP was also independent of any changes in the Ca(2+) transient. The mGluR-induced change in the firing pattern of hippocampal pyramidal cells is thus the result of multiple mechanisms, including suppression of both m and sAHPs and activation of an ADP, that act together to produce a specific excitatory effect, namely an increased likelihood that a single action potential will lead immediately to one or more following action potentials.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.