ArticleProceedings of the National Academy of Sciences of the United States of America2003
Axonal transport of eukaryotic translation elongation factor 1alpha mRNA couples transcription in the nucleus to long-term facilitation at the synapse.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 82 citations in OpenAlex.
- Small Differences and Big Changes: The Many Variables of MicroRNA Expression and Function in the Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Overexpressing eukaryotic elongation factor 1 alpha (eEF1A) proteins to promote corticospinal axon repair after injury.Cell death discovery · 2022Article
- Article
- Local Translation in Perisynaptic Astrocytic Processes Is Specific and Changes after Fear Conditioning.Cell reports · 2020Article
- Recent developments in transcriptional and translational regulation underlying long-term synaptic plasticity and memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Review
- Translational Control in the Brain in Health and Disease.Cold Spring Harbor perspectives in biology · 2019Review
- G Protein-Coupled Receptors As Regulators of Localized Translation: The Forgotten Pathway?Frontiers in endocrinology · 2018Review
- Hypoxia-ischemia modifies postsynaptic GluN2B-containing NMDA receptor complexes in the neonatal mouse brain.Experimental neurology · 2018Article
- Dysregulation of Elongation Factor 1A Expression is Correlated with Synaptic Plasticity Impairments in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2016Article
- Impaired Eukaryotic Elongation Factor 1A Expression in Alzheimer's Disease.Neuro-degenerative diseases · 2016Article
- Article
- Huntingtin is critical both pre- and postsynaptically for long-term learning-related synaptic plasticity in Aplysia.PloS one · 2014Article
- RNA transport and long-term memory storage.RNA biology · 2013Article
- Cell biology in neuroscience: RNA-based mechanisms underlying axon guidance.The Journal of cell biology · 2013Review
- A strategy to capture and characterize the synaptic transcriptome.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Spontaneous transmitter release recruits postsynaptic mechanisms of long-term and intermediate-term facilitation in Aplysia.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair.Nature reviews. Neuroscience · 2012Review
- Expression profiling reveals differential gene induction underlying specific and non-specific memory for pheromones in mice.Neurochemistry international · 2011Article
- Making memories last: the synaptic tagging and capture hypothesis.Nature reviews. Neuroscience · 2011Review
- A brief retraining regulates the persistence and lability of a long-term memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2010Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Long-term synaptic plasticity requires both gene expression in the nucleus and local protein synthesis at synapses. The effector proteins that link molecular events in the cell body with local maintenance of synaptic strength are not known. We now show that treatment with serotonin (5-HT) that produces long-term facilitation induces the Aplysia eukaryotic translation elongation factor 1alpha (Ap-eEF1A) as a late gene that might serve this coupling function in sensory neurons. Although the translation factor is induced, it is not transported into axon processes when the stimulation with 5-HT was restricted to the cell body. In contrast, its mRNA is transported when 5-HT was applied to both cell body and synapses. Intracellular injection of antisense oligonucleotides or antibodies that block the induction and expression of Ap-eEF1A do not affect the initial expression of long-term facilitation but do block its maintenance beyond 24 h. The transport of eEF1A protein and its mRNA to nerve terminals suggests that the translation factor plays a role in the local protein synthesis that is essential for maintaining newly formed synapses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.