ArticleMolecular biology of the cell1992
The nuclear-mitotic apparatus protein is important in the establishment and maintenance of the bipolar mitotic spindle apparatus.
Article in Molecular biology of the cell, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Article
- Sustainable integrative cell biology: CENP-C is guilty by association.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2025Article
- CDK5-cyclin B1 regulates mitotic fidelity.Nature · 2024Article
- Identifying GPSM Family Members as Potential Biomarkers in Breast Cancer: A Comprehensive Bioinformatics Analysis.Biomedicines · 2021Article
- The mitotic protein NuMA plays a spindle-independent role in nuclear formation and mechanics.The Journal of cell biology · 2020Article
- NuMA interaction with chromatin is vital for proper chromosome decondensation at the mitotic exit.Molecular biology of the cell · 2020Article
- PP2A--B55γ counteracts Cdk1 and regulates proper spindle orientation through the cortical dynein adaptor NuMA.Journal of cell science · 2020Article
- Plk1 regulates spindle orientation by phosphorylating NuMA in human cells.Life science alliance · 2018Article
- The Short Isoform of Nuclear Mitotic Apparatus Protein 1 Functions as a Putative Tumor Suppressor.Chinese medical journal · 2017Article
- Katanin p80, NuMA and cytoplasmic dynein cooperate to control microtubule dynamics.Scientific reports · 2017Article
- KSHV LANA--the master regulator of KSHV latency.Viruses · 2014Review
- NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane.The EMBO journal · 2014Article
- Cell cycle-regulated membrane binding of NuMA contributes to efficient anaphase chromosome separation.Molecular biology of the cell · 2014Article
- NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function.The EMBO journal · 2013Article
- NuMA after 30 years: the matrix revisited.Trends in cell biology · 2010Review
- NuMA is required for proper spindle assembly and chromosome alignment in prometaphase.BMC research notes · 2009Article
- Requirements for NuMA in maintenance and establishment of mammalian spindle poles.The Journal of cell biology · 2009Article
- Kaposi's sarcoma-associated herpesvirus-encoded LANA can interact with the nuclear mitotic apparatus protein to regulate genome maintenance and segregation.Journal of virology · 2008Article
- Downregulation of protein 4.1R, a mature centriole protein, disrupts centrosomes, alters cell cycle progression, and perturbs mitotic spindles and anaphase.Molecular and cellular biology · 2008Article
- NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis.The Biochemical journal · 2005Article
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2 authors.
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Abstract
The formation and maintenance of the bipolar mitotic spindle apparatus require a complex and balanced interplay of several mechanisms, including the stabilization and separation of polar microtubules and the action of various microtubule motors. Nonmicrotubule elements are also present throughout the spindle apparatus and have been proposed to provide a structural support for the spindle. The Nuclear-Mitotic Apparatus protein (NuMA) is an abundant 240 kD protein that is present in the nucleus of interphase cells and concentrates in the polar regions of the spindle apparatus during mitosis. Sequence analysis indicates that NuMA possesses an unusually long alpha-helical central region characteristic of many filament forming proteins. In this report we demonstrate that microinjection of anti-NuMA antibodies into interphase and prophase cells results in a failure to form a mitotic spindle apparatus. Furthermore, injection of metaphase cells results in the collapse of the spindle apparatus into a monopolar microtubule array. These results identify for the first time a nontubulin component important for both the establishment and stabilization of the mitotic spindle apparatus in multicellular organisms. We suggest that nonmicrotubule structural components may be important for these processes.
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