ArticleBMC genetics2003
Quantitative trait loci in Anopheles gambiae controlling the encapsulation response against Plasmodium cynomolgi Ceylon.
Article in BMC genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Non-Human Primate Malaria Infections: A Review on the Epidemiology in Malaysia.International journal of environmental research and public health · 2022Review
- "The Environment is Everything That Isn't Me": Molecular Mechanisms and Evolutionary Dynamics of Insect Clocks in Variable Surroundings.Frontiers in physiology · 2015Review
- The Anopheles innate immune system in the defense against malaria infection.Journal of innate immunity · 2014Review
- Some strains of Plasmodium falciparum, a human malaria parasite, evade the complement-like system of Anopheles gambiae mosquitoes.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Polymorphisms in Anopheles gambiae immune genes associated with natural resistance to Plasmodium falciparum.PLoS pathogens · 2010Article
- Anopheles immune genes and amino acid sites evolving under the effect of positive selection.PloS one · 2010Article
- Dissecting the genetic basis of resistance to malaria parasites in Anopheles gambiae.Science (New York, N.Y.) · 2009Article
- Article
- Silencing the genes for dopa decarboxylase or dopachrome conversion enzyme reduces melanization of foreign targets in Anopheles gambiae.Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology · 2008Article
- SNP discovery and molecular evolution in Anopheles gambiae, with special emphasis on innate immune system.BMC genomics · 2008Article
- Article
- Evidence for a population expansion in the West Nile virus vector Culex tarsalis.Molecular biology and evolution · 2007Article
- Fz2 and cdc42 mediate melanization and actin polymerization but are dispensable for Plasmodium killing in the mosquito midgut.PLoS pathogens · 2006Article
- Characterization of hemocytes from the mosquitoes Anopheles gambiae and Aedes aegypti.Insect biochemistry and molecular biology · 2006Article
- Article
- Article
- Evaluating the costs of mosquito resistance to malaria parasites.Evolution; international journal of organic evolution · 2005Article
- Host genotype by parasite genotype interactions underlying the resistance of anopheline mosquitoes to Plasmodium falciparum.Malaria journal · 2005Article
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6 authors.
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Abstract
backgroundAnopheles gambiae females are the world's most successful vectors of human malaria. However, a fraction of these mosquitoes is refractory to Plasmodium development. L3-5, a laboratory selected refractory strain, encapsulates transforming ookinetes/early oocysts of a wide variety of Plasmodium species. Previous studies on these mosquitoes showed that one major (Pen1) and two minor (Pen2, Pen3) autosomal dominant quantitative trait loci (QTLs) control the melanotic encapsulation response against P. cynomolgi B, a simian malaria originating in Malaysia.
resultsWe have investigated the response of L3-5 to infection with P. cynomolgi Ceylon, a different but related parasite species, in crosses with the susceptible strain 4Arr. Refractoriness to this parasite is incompletely recessive. Infection and genotyping of F2 intercross females at genome-spanning microsatellite loci revealed that 3 autosomal QTLs control encapsulation of this species. Two loci map to the regions containing Pen2 and Pen3. The novel QTL maps to chromosome 3R, probably to polytene division 32 or 33. Thus the relative contribution of any QTL to oocyst encapsulation varies with the species of parasite. Further, different QTLs were most readily identified in different F2 families. This, like the F1 data, suggests that L3-5 is not genetically homogeneous and that somewhat different pathways may be used to achieve an encapsulation response.
conclusionWe have shown here that different QTLs are involved in responses against different Plasmodium parasites.
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