ArticlePediatric nephrology (Berlin, Germany)2003
The effects of corticosteroids on behavior in children with nephrotic syndrome.
Article in Pediatric nephrology (Berlin, Germany), 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Psychiatric Symptoms Associated with Corticosteroid Use: A Systematic Review and Meta-analysis.CNS drugs · 2026Pooled it
- Systematic review of the toxicity of short-course oral corticosteroids in children.Archives of disease in childhood · 2016Pooled it
- Efficacy of higher-dose levamisole in maintaining remission in steroid-dependant nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2017Trial
- Cases of Psychiatric Morbidity in Pediatric Patients After Remission of Cushing Syndrome.Pediatrics · 2016Trial
- Trial
- Increased behavioural problems associated with corticosteroid use in children with nephrotic syndrome: a Southeast Asian perspective.Singapore medical journal · 2023Article
- Optimizing the corticosteroid dose in steroid-sensitive nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2022Review
- Impact of steroids and steroid-sparing agents on quality of life in children with nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2021Article
- Preliminary Research on Syndrome Types of Chinese Medicine in Children with Primary Nephrotic Syndrome.Chinese journal of integrative medicine · 2018Article
- Use of a low-dose prednisolone regimen to treat a relapse of steroid-sensitive nephrotic syndrome in children.Pediatric nephrology (Berlin, Germany) · 2017Article
- Zinc supplementation as an adjunct to standard therapy in childhood nephrotic syndrome - a systematic review.World journal of clinical pediatrics · 2016Article
- Eosinophilic gastroenteritis in an 18-year-old male with prolonged nephrotic syndrome.Korean journal of pediatrics · 2016Article
- Behavioural abnormalities in children with new-onset nephrotic syndrome receiving corticosteroid therapy: results of a prospective longitudinal study.Pediatric nephrology (Berlin, Germany) · 2016Article
- Steroid-sensitive nephrotic syndrome in children: triggers of relapse and evolving hypotheses on pathogenesis.Italian journal of pediatrics · 2015Review
- Impact of rituximab on height and weight in children with refractory steroid-dependent nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2014Article
- Psychosocial and cognitive function in children with nephrotic syndrome: association with disease and treatment variables.BioPsychoSocial medicine · 2013Article
- Psychosocial and emotional adjustment for children with pediatric cancer and their primary caregivers and the impact on their health-related quality of life during the first 6 months.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2013Article
- The rationale and design of Insight into Nephrotic Syndrome: Investigating Genes, Health and Therapeutics (INSIGHT): a prospective cohort study of childhood nephrotic syndrome.BMC nephrology · 2013Article
- Assessment of behavior abnormalities of corticosteroids in children with nephrotic syndrome.ISRN psychiatry · 2013Article
- Complications of nephrotic syndrome.Korean journal of pediatrics · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to measure the frequency and severity of the behavioral effects of high-dose oral steroid therapy in children with nephrotic syndrome. We conducted a prospective assessment of the behavior of 12 children using a standardized psychological questionnaire at the time of diagnosis and again after 4 weeks of steroid therapy. A group of control children was also assessed. There was a significant increase in the total behavior score ( P=0.03) and specifically in aggressive and poor attention behavior items in the group of nephrotic children compared with the control group. Four of the children with nephrotic syndrome developed abnormal behavior in the clinical range compared with none of the controls. In conclusion, children with nephrotic syndrome treated with high-dose oral steroids are at risk of developing clinically relevant behavioral changes.
Indexed as
Identifiers
14577022What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.