ArticleDiabetologia2003
Peroxisome proliferator-activated receptor gamma coactivator-1-dependent uncoupling protein-2 expression in pancreatic islets of rats: a novel pathway for neural control of insulin secretion.
Article in Diabetologia, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Association of PGC-1α gene with type 2 diabetes in three unrelated endogamous groups of North-West India (Punjab): a case-control and meta-analysis study.Molecular genetics and genomics : MGG · 2018Pooled it
- Sodium-glucose cotransporter 2 inhibitors facilitate cell phenotype conversion of alpha cells through progenitors to beta cells by activating Ppargc1α in diabetic mice.Chinese medical journal · 2026Article
- Review
- The Role of PGC-1α and Mitochondrial Biogenesis in Kidney Diseases.Biomolecules · 2020Review
- PGC-1α activation: a therapeutic target for type 2 diabetes?Eating and weight disorders : EWD · 2019Review
- A20 deubiquitinase controls PGC-1α expression in the adipose tissue.Lipids in health and disease · 2018Article
- Lithium and Tamoxifen Modulate Behavior and Protein Kinase C Activity in the Animal Model of Mania Induced by Ouabain.The international journal of neuropsychopharmacology · 2017Article
- Circadian control of β-cell function and stress responses.Diabetes, obesity & metabolism · 2015Review
- Gastrin-releasing peptide receptor antagonism induces protection from lethal sepsis: involvement of toll-like receptor 4 signaling.Molecular medicine (Cambridge, Mass.) · 2012Article
- Oxidative damage, inflammation, and Toll-like receptor 4 pathway are increased in preeclamptic patients: a case-control study.Oxidative medicine and cellular longevity · 2012Article
- Inflammation of the hypothalamus leads to defective pancreatic islet function.The Journal of biological chemistry · 2011Article
- PGC-1 coactivators in the control of energy metabolism.Acta biochimica et biophysica Sinica · 2011Review
- Dynamic regulation of uncoupling protein 2 content in INS-1E insulinoma cells.Biochimica et biophysica acta · 2008Article
- Uncoupling protein-2 modulates the lipid metabolic response to fasting in mice.American journal of physiology. Gastrointestinal and liver physiology · 2008Article
- Role of mitochondria in the immune response to cancer: a central role for Ca2+.Journal of bioenergetics and biomembranes · 2006Article
- Article
- beta3-Adrenergic-dependent and -independent mechanisms participate in cold-induced modulation of insulin signal transduction in brown adipose tissue of rats.Pflugers Archiv : European journal of physiology · 2005Article
- Expression and functional activity of PPARgamma in pancreatic beta cells.British journal of pharmacology · 2004Article
- The regulation and turnover of mitochondrial uncoupling proteins.Biochimica et biophysica actaReview
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisSympathetic inputs inhibit insulin secretion through alpha2-adrenergic receptors coupled with Gi protein. High adrenergic tonus generated by exposure of homeothermic animals to cold reduces insulin secretion. In this study we evaluate the participation of UCP-2 in cold-induced regulation of insulin secretion.
methodsStatic insulin secretion studies, western blotting and immunohistochemistry were used in this investigation.
resultsExposure of rats to cold during 8 days promoted 60% ( n=15, p<0.05) reduction of basal serum insulin levels concentration accompanied by reduction of the area under insulin curve during i.p. GTT (50%, n=15, p<0.05). Isolated islets from cold-exposed rats secreted 57% ( n=6, p<0.05) less insulin following a glucose challenge. Previous sympathectomy, partially prevented the effect of cold exposure upon insulin secretion. Islets isolated from cold-exposed rats expressed 51% ( n=6, p<0.5) more UCP-2 than islets from control rats, while the inhibition of UCP-2 expression by antisense oligonucleotide treatment partially restored insulin secretion of islets obtained from cold-exposed rats. Cold exposure also induced an increase of 69% ( n=6, p<0.05) in PGC-1 protein content in pancreatic islets. Inhibition of islet PGC-1 expression by antisense oligonucleotide abrogated cold-induced UCP-2 expression and partially restored insulin secretion in islets exposed to cold. CONCLUSION/
interpretationOur data indicate that sympathetic tonus generated by exposure of rats to cold induces the expression of PGC-1, which participates in the control of UCP-2 expression in pancreatic islets. Increased UCP-2 expression under these conditions could reduce the beta-cell ATP/ADP ratio and negatively regulate insulin secretion.
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