ArticleOncogene2003
Molecular analysis of transitional cell carcinoma using cDNA microarray.
Article in Oncogene, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- Review
- Downregulation of Rab17 promotes cell proliferation and invasion in non-small cell lung cancer through STAT3/HIF-1α/VEGF signaling.Thoracic cancer · 2020Article
- Downregulation of Rab25 activates Akt1 in head and neck squamous cell carcinoma.Oncology letters · 2015Article
- Rab11 in disease progression.International journal of molecular and cellular medicine · 2015Review
- Regulation of autophagy by the Rab GTPase network.Cell death and differentiation · 2014Review
- Gene expression is highly correlated on the chromosome level in urinary bladder cancer.Cell cycle (Georgetown, Tex.) · 2013Article
- Increased expression of Rab25 in breast cancer correlates with lymphatic metastasis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Article
- Differential expression of Rab27A/B correlates with clinical outcome in hepatocellular carcinoma.World journal of gastroenterology · 2012Article
- Rab GTPases, membrane trafficking and diseases.Current drug targets · 2011Review
- Article
- Transformation of rat intestinal epithelial cells by overexpression of Rab25 is microtubule dependent.Cytoskeleton (Hoboken, N.J.) · 2011Article
- Molecular targets of alcohol action: Translational research for pharmacotherapy development and screening.Progress in molecular biology and translational science · 2011Review
- Integrin-mediated function of Rab GTPases in cancer progression.Molecular cancer · 2010Review
- The emerging role of the RAB25 small GTPase in cancer.Traffic (Copenhagen, Denmark) · 2009Review
- Activation of the PI3K/AKT pathway induces urothelial carcinoma of the renal pelvis: identification in human tumors and confirmation in animal models.Cancer research · 2009Article
- Molecular characterization of early-stage bladder carcinomas by expression profiles, FGFR3 mutation status, and loss of 9q.Oncogene · 2006Article
- Analysis of the interaction of extracellular matrix and phenotype of bladder cancer cells.BMC cancer · 2006Article
- Cell type-specific analyses for identifying prostate cancer biomarkers.Current urology reports · 2006Review
- Gene expression profiling of noninvasive primary urothelial tumours using microarrays.British journal of cancer · 2005Article
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The incidence of transitional cell carcinoma (TCC), the fourth most common neoplasm diagnosed in men, is rising. Despite the development of several noninvasive diagnostic tests, none have gained full recognition by the clinicians. Gene expression profiling of tumors can identify new molecular markers for early diagnosis and disease follow-up. It also allows the classification of tumors into subclasses assisting in disease diagnosis and prognosis, as well as in treatment selection. In this paper, we employed expression profiling for molecular analysis of TCC. A TCC-derived cDNA microarray was constructed and hybridized with 19 probes from normal urothelium and TCC tissues. Hierarchical clustering analysis identified all normal urothelium samples to be tightly clustered and separated from the TCC samples, with 29 of the genes significantly induced (t-test, P<10(-5)) in noninvasive TCC compared to normal urothelium. The identified genes are involved in epithelial cells' functions, tumorigenesis or apoptosis, and could become molecular tools for noninvasive TCC diagnosis. Principal components analysis of the noninvasive and invasive TCC expression profiles further revealed sets of genes that are specifically induced in different tumor subsets, thus providing molecular fingerprints that expand the information gained from classical staging and grading.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.