ArticleOncogene2003
12p-amplicon structure analysis in testicular germ cell tumors of adolescents and adults by array CGH.
Article in Oncogene, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Report From the International Society of Urological Pathology (ISUP) Consultation Conference on Molecular Pathology of Urogenital Cancers: IV: Current and Future Utilization of Molecular-Genetic Tests for Testicular Germ Cell Tumors.The American journal of surgical pathology · 2020Guideline
- Cripto: Expression, epigenetic regulation and potential diagnostic use in testicular germ cell tumors.Molecular oncology · 2016Trial
- Frequent copy number gains of SLC2A3 and ETV1 in testicular embryonal carcinomas.Endocrine-related cancer · 2020Article
- Predicting Gonadal Germ Cell Cancer in People with Disorders of Sex Development; Insights from Developmental Biology.International journal of molecular sciences · 2019Review
- c-Src Recruitment is Involved in c-MET-Mediated Malignant Behaviour of NT2D1 Non-Seminoma Cells.International journal of molecular sciences · 2019Article
- c-MET receptor as potential biomarker and target molecule for malignant testicular germ cell tumors.Oncotarget · 2018Article
- IGF1R signalling in testicular germ cell tumour cells impacts on cell survival and acquired cisplatin resistance.The Journal of pathology · 2018Article
- Testicular cancer in two brothers of a quadruplet: a case report and a review of literature.Acta medica Lituanic · 2017Article
- The genomic landscape of testicular germ cell tumours: from susceptibility to treatment.Nature reviews. Urology · 2016Review
- Whole-exome sequencing reveals the mutational spectrum of testicular germ cell tumours.Nature communications · 2015Article
- Genomic screening of testicular germ cell tumors from monozygotic twins.Orphanet journal of rare diseases · 2014Article
- Aneuploidy in pluripotent stem cells and implications for cancerous transformation.Protein & cell · 2014Review
- Testicular germ cell tumours: predisposition genes and the male germ cell niche.Nature reviews. Cancer · 2011Review
- Genetic copy number variants in sib pairs both affected with schizophrenia.Journal of biomedical science · 2010Article
- A census of amplified and overexpressed human cancer genes.Nature reviews. Cancer · 2010Review
- [Molecular pathology of testicular germ cell tumors: an update].Der Pathologe · 2008Article
- Separation and maintenance of normal cells from human embryonic stem cells with trisomy 12 mosaicism.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Article
- Genomic copy number and expression patterns in testicular germ cell tumours.British journal of cancer · 2007Article
- The Y-encoded TSPY protein: a significant marker potentially plays a role in the pathogenesis of testicular germ cell tumors.Human pathology · 2007Article
- Microinvasive germ cell tumor of the testis.Virchows Archiv : an international journal of pathology · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
All invasive testicular germ cell tumors of adolescents and adults (TGCTs), that is, seminomas and nonseminomas, show gain of 12p sequences, mostly as isochromosomes. Although several candidate genes have been suggested, the relevant gene(s) have not been identified yet. About 10% of testicular seminomas, however, show a more restricted amplification of the 12p11.2-p12.1 region, in which the various amplicons show an apparent overlap, allowing for the shortest region of amplification overlap approach, aiming at the identification of pathogenetically relevant sequences residing in this region. Here we report on a high-resolution 12p-amplicon architecture analysis using microarray-based comparative genomic hybridization, the results of which were subsequently confirmed by fluorescent in situ hybridization studies. The 12p-specific microarray contained 63 positionally selected BAC clones, which are more or less evenly distributed over the short arm of chromosome 12 (average spacing: less than 500 Kb), including 20 clones within the region of amplification. Out of a series of 17 seminomas, seven seminomas showed amplification of the whole amplicon region, of which three showed a dip in T/R value in the center of the amplified area. A more complex amplification pattern was found in the other 10 seminomas: three showed predominant amplification at the centromeric border; one mainly at the telomeric border; six showed a balanced amplification of both the centromeric and telomeric regions. The only nonseminoma investigated showed a structure in which the centromeric border was only amplified. These data support a mechanistic model in which at least two 12p genes, situated at the border regions of the amplicon, are positional candidates capable of actively supporting tumor progression in TGCTs.
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