ArticleOncogene2003
Oncogenes, tumor suppressors and p52 NF-kappaB.
Article in Oncogene, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Association of CRP genetic variants with blood concentrations of C-reactive protein and colorectal cancer risk.International journal of cancer · 2015Trial
- ADAMTS7 Enhances Gastric Cancer Growth and Metastasis by Triggering the NF-κB Signaling Pathway.Journal of Cancer · 2025Article
- The Elevated Pre-Treatment C-Reactive Protein Predicts Poor Prognosis in Patients with Locally Advanced Rectal Cancer Treated with Neo-Adjuvant Radiochemotherapy.Diagnostics (Basel, Switzerland) · 2020Article
- CD147 regulates extrinsic apoptosis in spermatocytes by modulating NFκB signaling pathways.Oncotarget · 2017Article
- Macrophage polarization: the link between inflammation and related diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Review
- Inhibitory effect of 5F on development of lung cancer in A/J mice.International journal of clinical and experimental pathology · 2015Article
- Chronic inflammation and cancer: potential chemoprevention through nuclear factor kappa B and p53 mutual antagonism.Journal of inflammation (London, England) · 2014Review
- Molecular cloning and characterization of an IKK homologue from amphioxus (Branchiostoma belcheri).Molecular biology reports · 2012Article
- Myc suppression of Nfkb2 accelerates lymphomagenesis.BMC cancer · 2010Article
- LMP1-augmented kappa intron enhancer activity contributes to upregulation expression of Ig kappa light chain via NF-kappaB and AP-1 pathways in nasopharyngeal carcinoma cells.Molecular cancer · 2009Article
- The role of the NFkappaB signalling pathway in cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2008Review
- Stat3 activation of NF-{kappa}B p100 processing involves CBP/p300-mediated acetylation.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- NIBP, a novel NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation.The Journal of biological chemistry · 2005Article
- Modulation of p53 activity by IkappaBalpha: evidence suggesting a common phylogeny between NF-kappaB and p53 transcription factors.BMC immunology · 2005Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A role for the p52 NF-kappaB subunit in tumorigenesis has been steadily emerging since its discovery as a gene associated with chromosomal translocations in B- and T-cell lymphomas. Now Eliopoulos and co-workers have extended these studies to examine the effect of the Epstein-Barr virus (EBV)-encoded latent infection membrane protein 1 (LMP1) on p52. They find that LMP1 stimulates the processing of p100 to p52 NF-kappaB. Moreover, nuclear p52 is also associated with LMP1 expression in tumor tissue biopsies. They also demonstrate that the pathway leading to p100/p52 processing is distinct from that engaged by LMP1 to activate other NF-kappaB subunits through IkappaBalpha degradation. A clearer picture is now developing of the important role that p52 NF-kappaB plays during normal cell growth and how subverting its function can contribute to oncogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.