ArticleNucleic acids research2003
Transcriptional response to DNA damage in the archaeon Sulfolobus solfataricus.
Article in Nucleic acids research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Sulfolobus islandicus Employs Orc1-2-Mediated DNA Damage Response in Defense against Infection by SSV2.Journal of virology · 2022Article
- Participation of UV-regulated Genes in the Response to Helix-distorting DNA Damage in the Thermoacidophilic Crenarchaeon Sulfolobus acidocaldarius.Microbes and environments · 2019Article
- Increase of positive supercoiling in a hyperthermophilic archaeon after UV irradiation.Extremophiles : life under extreme conditions · 2019Article
- An Orc1/Cdc6 ortholog functions as a key regulator in the DNA damage response in Archaea.Nucleic acids research · 2018Article
- DNA Processing Proteins Involved in the UV-Induced Stress Response of Sulfolobales.Journal of bacteriology · 2015Article
- A standardized protocol for the UV induction of Sulfolobus spindle-shaped virus 1.Extremophiles : life under extreme conditions · 2015Article
- Chromatin structure and dynamics in hot environments: architectural proteins and DNA topoisomerases of thermophilic archaea.International journal of molecular sciences · 2014Review
- Genome stability: recent insights in the topoisomerase reverse gyrase and thermophilic DNA alkyltransferase.Extremophiles : life under extreme conditions · 2014Review
- Single-stranded DNA binding activity of XPBI, but not XPBII, from Sulfolobus tokodaii causes double-stranded DNA melting.Extremophiles : life under extreme conditions · 2011Article
- The archaeal topoisomerase reverse gyrase is a helix-destabilizing protein that unwinds four-way DNA junctions.The Journal of biological chemistry · 2010Article
- Structural and functional characterisation of a conserved archaeal RadA paralog with antirecombinase activity.Journal of molecular biology · 2009Article
- Transcriptional responses to biologically relevant doses of UV-B radiation in the model archaeon, Halobacterium sp. NRC-1.Saline systems · 2008Article
- The in vitro activity of a Rad55 homologue from Sulfolobus tokodaii, a candidate mediator in RadA-catalyzed homologous recombination.Extremophiles : life under extreme conditions · 2008Article
- Response of the hyperthermophilic archaeon Sulfolobus solfataricus to UV damage.Journal of bacteriology · 2007Article
- Sister chromatid junctions in the hyperthermophilic archaeon Sulfolobus solfataricus.The EMBO journal · 2007Article
- Responses of hyperthermophilic crenarchaea to UV irradiation.Genome biology · 2007Article
- The Sulfolobus solfataricus radA paralogue sso0777 is DNA damage inducible and positively regulated by the Sta1 protein.Nucleic acids research · 2007Article
- Microarray analysis of the hyperthermophilic archaeon Pyrococcus furiosus exposed to gamma irradiation.Extremophiles : life under extreme conditions · 2007Article
- The uvrA, uvrB and uvrC genes are required for repair of ultraviolet light induced DNA photoproducts in Halobacterium sp. NRC-1.Saline systems · 2006Article
- Selective degradation of reverse gyrase and DNA fragmentation induced by alkylating agent in the archaeon Sulfolobus solfataricus.Nucleic acids research · 2006Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exposure of cells to DNA-damaging agents triggers a complex biological response involving cell cycle arrest and modulation of gene expression. Genomic sequencing has revealed the presence of archaeal genes homologous to components of the eucaryal nucleotide excision repair (NER) pathway, which is involved in the repair of ultraviolet (UV) light-induced DNA damage. However, the events involved in the cell response to UV irradiation and their regulation have not been studied in Archaea. We show here that UV radiation induces the formation of cyclobutane pyrimidine dimers (CPDs) in the hyperthermophilic archaeon Sulfolobus solfataricus, and that these lesions are efficiently repaired in vivo in the dark, suggesting that a NER pathway is active. DNA damage is a signal for concomitant growth arrest and transcriptional induction of the NER genes XPF, XPG and XPB. The cell response to UV irradiation includes transcriptional regulation of genes encoding two DNA binding proteins involved in chromosome dynamics. Moreover, several of these genes are also strongly induced by the intercalating agent actinomycin D. Thus, response to DNA damage in S.solfataricus has features essentially conserved in all three domains of life.
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