ReviewNucleic acids research2003
Therapeutic modulation of endogenous gene function by agents with designed DNA-sequence specificities.
Review in Nucleic acids research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 92 citations in OpenAlex.
- Epigenetic editing: from concept to clinic.Nature reviews. Drug discovery · 2026Review
- H-ACO with Consecutive Bases Pairing Constraint for Designing DNA Sequences.Interdisciplinary sciences, computational life sciences · 2024Article
- How acidic amino acid residues facilitate DNA target site selection.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- DNA with zwitterionic and negatively charged phosphate modifications: Formation of DNA triplexes, duplexes and cell uptake studies.Beilstein journal of organic chemistry · 2021Article
- RNA Biology Provides New Therapeutic Targets for Human Disease.Frontiers in genetics · 2019Review
- The past and presence of gene targeting: from chemicals and DNA via proteins to RNA.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Sliding on DNA: From Peptides to Small Molecules.Angewandte Chemie (International ed. in English) · 2016Article
- Article
- Current and upcoming approaches to exploit the reversibility of epigenetic mutations in breast cancer.Breast cancer research : BCR · 2014Review
- Functional validation of putative tumor suppressor gene C13ORF18 in cervical cancer by Artificial Transcription Factors.Molecular oncology · 2013Article
- Bidirectional modulation of endogenous EpCAM expression to unravel its function in ovarian cancer.British journal of cancer · 2013Article
- Optimizing scoring function of protein-nucleic acid interactions with both affinity and specificity.PloS one · 2013Article
- Epigenetic Editing: targeted rewriting of epigenetic marks to modulate expression of selected target genes.Nucleic acids research · 2012Review
- Double-helix disruption.Nature chemistry · 2012Article
- DNA complexes: Durable binders.Nature chemistry · 2011Article
- Optimizing anti-gene oligonucleotide 'Zorro-LNA' for improved strand invasion into duplex DNA.Nucleic acids research · 2011Article
- Selection of RNA aptamers that bind HIV-1 LTR DNA duplexes: strand invaders.Nucleic acids research · 2010Article
- A novel FRET pair for detection of parallel DNA triplexes by the LightCycler.BMC biotechnology · 2010Article
- Influence of substituent modifications on the binding of 2-amino-1,8-naphthyridines to cytosine opposite an AP site in DNA duplexes: thermodynamic characterization.Nucleic acids research · 2009Article
- Netropsin improves survival from endotoxaemia by disrupting HMGA1 binding to the NOS2 promoter.The Biochemical journal · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Designer molecules that can specifically target pre-determined DNA sequences provide a means to modulate endogenous gene function. Different classes of sequence-specific DNA-binding agents have been developed, including triplex-forming molecules, synthetic polyamides and designer zinc finger proteins. These different types of designer molecules with their different principles of engineered sequence specificity are reviewed in this paper. Furthermore, we explore and discuss the potential of these molecules as therapeutic modulators of endogenous gene function, focusing on modulation by stable gene modification and by regulation of gene transcription.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.