ArticleProceedings of the National Academy of Sciences of the United States of America2003
Convergent neofunctionalization by positive Darwinian selection after ancient recurrent duplications of the xanthine dehydrogenase gene.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39 citing papers in PubMed, 145 citations in OpenAlex.
- Review
- Transcription Factors Evolve Faster Than Their Structural Gene Targets in the Flavonoid Pigment Pathway.Molecular biology and evolution · 2022Article
- Adaptive evolution driving the young duplications in six Rosaceae species.BMC genomics · 2021Article
- Integrated structural and evolutionary analysis reveals common mechanisms underlying adaptive evolution in mammals.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Genome-Scale Metabolic Networks Shed Light on the Carotenoid Biosynthesis Pathway in the Brown AlgaeAntioxidants (Basel, Switzerland) · 2019Article
- Magic roundabout is an endothelial-specific ohnolog of ROBO1 which neo-functionalized to an essential new role in angiogenesis.PloS one · 2019Article
- From the Eukaryotic Molybdenum Cofactor Biosynthesis to the Moonlighting Enzyme mARC.Molecules (Basel, Switzerland) · 2018Review
- Aldehyde Oxidase 4 Plays a Critical Role in Delaying Silique Senescence by Catalyzing Aldehyde Detoxification.Plant physiology · 2017Article
- From molecules to mating: Rapid evolution and biochemical studies of reproductive proteins.Journal of proteomics · 2016Review
- Evolution ofBioMed research international · 2016Article
- Phylogeny and evolution of plant macrophage migration inhibitory factor/D-dopachrome tautomerase-like proteins.BMC evolutionary biology · 2015Article
- Neofunctionalization of duplicated Tic40 genes caused a gain-of-function variation related to male fertility in Brassica oleracea lineages.Plant physiology · 2014Article
- The four aldehyde oxidases of Drosophila melanogaster have different gene expression patterns and enzyme substrate specificities.The Journal of experimental biology · 2014Article
- Molybdenum metabolism in plants and crosstalk to iron.Frontiers in plant science · 2014Review
- Article
- Structure and evolution of vertebrate aldehyde oxidases: from gene duplication to gene suppression.Cellular and molecular life sciences : CMLS · 2013Article
- Evolution of homospermidine synthase in the convolvulaceae: a story of gene duplication, gene loss, and periods of various selection pressures.The Plant cell · 2013Article
- Diversification of the expanded teleost-specific toll-like receptor family in Atlantic cod, Gadus morhua.BMC evolutionary biology · 2012Article
- Identification of superoxide production by Arabidopsis thaliana aldehyde oxidases AAO1 and AAO3.Plant molecular biology · 2012Article
- The first mammalian aldehyde oxidase crystal structure: insights into substrate specificity.The Journal of biological chemistry · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Gene duplication is a primary source of molecular substrate for the emergence of evolutionary novelties. The chances for redundant gene sequences to evolve new functions are small compared with the probability that the copies become disabled by deleterious mutations. Functional divergence after gene duplication can result in two alternative evolutionary fates: one copy acquires a novel function (neofunctionalization), or each copy adopts part of the tasks of their parental gene (subfunctionalization). The relative prevalence of each outcome is unknown. Similarly unknown is the relative importance of positive selection versus random fixation of neutral mutations. Aldehyde oxidase (Ao) and xanthine dehydrogenase (Xdh) genes encode two complex members of the xanthine oxidase family of molybdo-flavoenzymes that carry different functions. Ao is known to have originated from a duplicate of an Xdh gene in eukaryotes, before the origin of multicellularity. We show that (i) Ao evolved independently twice from two different Xdh paralogs, the second time in the chordates, before the diversification of vertebrates; (ii) after each duplication, the Ao duplicate underwent a period of rapid evolution during which identical sites across the two molecules, involving the flavin adenine dinucleotide and substrate-binding pockets, were subjected to intense positive Darwinian selection; and (iii) the second Ao gene likely endured two periods of redundancy, initially as a duplicate of Xdh and later as a functional equivalent of the old Ao, which is currently absent from the vertebrate genome. Caution is appropriate in structural genomics when using sequence similarity for assigning protein function.
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